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gcst-1 Aminomethyltransferase [ Caenorhabditis elegans ]

Gene ID: 178960, updated on 2-Nov-2024

Summary

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Official Symbol
gcst-1
Official Full Name
Aminomethyltransferase
Primary source
WormBase:WBGene00017765
Locus tag
CELE_F25B4.1
See related
AllianceGenome:WB:WBGene00017765
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable aminomethyltransferase activity and transaminase activity. Predicted to be involved in glycine catabolic process. Predicted to be active in mitochondrion. Is expressed in body wall musculature; hypodermis; intestine; and pharynx. Human ortholog(s) of this gene implicated in glycine encephalopathy. Orthologous to human AMT (aminomethyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gcst-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
4
Sequence:
Chromosome: V; NC_003283.11 (5712928..5714737)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Protein pellino Neighboring gene Neuropeptide CCHamide-1 Neighboring gene ncRNA Neighboring gene Rho-GAP domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Integration of metabolic and gene regulatory networks modulates the C. elegans dietary response. Watson E, et al. Cell, 2013 Mar 28. PMID 23540702, Free PMC Article
  2. Trifunctional cross-linker for mapping protein-protein interaction networks and comparing protein conformational states. Tan D, et al. Elife, 2016 Mar 8. PMID 26952210, Free PMC Article
  3. SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans. Robert VJ, et al. Development, 2023 Nov 1. PMID 37818613, Free PMC Article
  4. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
  5. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables aminomethyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transaminase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glycine catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Aminomethyltransferase
NP_504502.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    5712928..5714737
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_072101.6 → NP_504502.1  Aminomethyltransferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_504502.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q22968
    Conserved Domains (3) summary
    PLN02319
    Location:2 → 399
    PLN02319; aminomethyltransferase
    pfam01571
    Location:34 → 287
    GCV_T; Aminomethyltransferase folate-binding domain
    pfam08669
    Location:297 → 391
    GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain
Nucleotide Protein
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