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pgph-2 Phosphoglycolate phosphatase [ Caenorhabditis elegans ]

Gene ID: 178965, updated on 2-Nov-2024

Summary

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Official Symbol
pgph-2
Official Full Name
Phosphoglycolate phosphatase
Primary source
WormBase:WBGene00018424
Locus tag
CELE_F44E7.2
See related
AllianceGenome:WB:WBGene00018424
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable phosphatase activity. Predicted to be active in cytoplasm. Is expressed in hypodermis; intestinal muscle; and nervous system. Orthologous to human PGP (phosphoglycolate phosphatase) and PDXP (pyridoxal phosphatase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pgph-2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
3
Sequence:
Chromosome: V; NC_003283.11 (5770456..5771766)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene YDG domain-containing protein Neighboring gene F-box domain-containing protein Neighboring gene Phosphoglycolate phosphatase Neighboring gene t-SNARE coiled-coil homology domain-containing protein Neighboring gene Insulin-degrading enzyme

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phosphoglycolate phosphatase homologs act as glycerol-3-phosphate phosphatase to control stress and healthspan in C. elegans. Possik E, et al. Nat Commun, 2022 Jan 11. PMID 35017476, Free PMC Article
  2. Glycerol 3-phosphate phosphatase/PGPH-2 counters metabolic stress and promotes healthy aging via a glycogen sensing-AMPK-HLH-30-autophagy axis in C. elegans. Possik E, et al. Nat Commun, 2023 Aug 25. PMID 37626039, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phosphoglycolate phosphatase homologs act as glycerol-3-phosphate phosphatase to control stress and healthspan in C. elegans.
    Title: Phosphoglycolate phosphatase homologs act as glycerol-3-phosphate phosphatase to control stress and healthspan in C. elegans.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Phosphoglycolate phosphatase
NP_504512.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    5770456..5771766
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_072111.7 → NP_504512.1  Phosphoglycolate phosphatase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_504512.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O16247
    Conserved Domains (3) summary
    TIGR01452
    Location:45 → 330
    PGP_euk; phosphoglycolate/pyridoxal phosphate phosphatase family
    pfam13242
    Location:251 → 330
    Hydrolase_like; HAD-hyrolase-like
    pfam13344
    Location:49 → 153
    Hydrolase_6; Haloacid dehalogenase-like hydrolase
Nucleotide Protein
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