lrpr-1 Leucine Rich Pentatricopeptide Repeat homolog;RAP domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: lrpr-1
Official Full Name: Leucine Rich Pentatricopeptide Repeat homolog;RAP domain-containing protein
Primary source: WormBase:WBGene00015425
Locus tag: CELE_C04E6.11
See related: AllianceGenome:WB:WBGene00015425
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable mRNA 3'-UTR binding activity. Predicted to be involved in regulation of mitochondrial translation. Predicted to be active in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in French Canadian Leigh disease and Leigh disease. Orthologous to human LRPPRC (leucine rich pentatricopeptide repeat containing). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See lrpr-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 13

Sequence:: Chromosome: V; NC_003283.11 (5914093..5917891, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C04E6.11 (e-PCR)
- UniSTS:308458

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in regulation of mitochondrial translation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Leucine Rich Pentatricopeptide Repeat homolog;RAP domain-containing protein

NP_001412560.1

Product from WormBase gene class lrpr;
Confirmed by transcript evidence

NP_504540.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

5914093..5917891 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_072139.5 → NP_504540.2 RAP domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_504540.2

Status: REVIEWED

UniProtKB/TrEMBL

O01470

Conserved Domains (1) summary

sd00004
Location:189 → 218

PPR; PPR repeat [structural motif]
NM_001425619.1 → NP_001412560.1 Leucine Rich Pentatricopeptide Repeat homolog [Caenorhabditis elegans]

Status: REVIEWED