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mcp-1 GDP-D-glucose phosphorylase 1 [ Caenorhabditis elegans ]

Gene ID: 178982, updated on 2-Nov-2024

Summary

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Official Symbol
mcp-1
Official Full Name
GDP-D-glucose phosphorylase 1
Primary source
WormBase:WBGene00015678
Locus tag
CELE_C10F3.4
See related
AllianceGenome:WB:WBGene00015678
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables GDP-D-glucose phosphorylase activity. Involved in glucose metabolic process. Located in cytoplasm. Is expressed in anterior hypodermis; nervous system; and reproductive system. Orthologous to human GDPGP1 (GDP-D-glucose phosphorylase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mcp-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
12
Sequence:
Chromosome: V; NC_003283.11 (5961874..5969173)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Protein-L-isoaspartate O-methyltransferase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Antibody responses against the vaccine antigens Ov-103 and Ov-RAL-2 are associated with protective immunity to Onchocerca volvulus infection in both mice and humans. George PJ, et al. PLoS Negl Trop Dis, 2019 Sep. PMID 31525197, Free PMC Article
  2. The L-isoaspartyl-O-methyltransferase in Caenorhabditis elegans larval longevity and autophagy. Gomez TA, et al. Dev Biol, 2007 Mar 15. PMID 17187774, Free PMC Article
  3. A novel GDP-D-glucose phosphorylase involved in quality control of the nucleoside diphosphate sugar pool in Caenorhabditis elegans and mammals. Adler LN, et al. J Biol Chem, 2011 Jun 17. PMID 21507950, Free PMC Article
  4. Defective responses to oxidative stress in protein l-isoaspartyl repair-deficient Caenorhabditis elegans. Khare S, et al. Mech Ageing Dev, 2009 Oct. PMID 19682488, Free PMC Article
  5. The stress-responsive gene GDPGP1/mcp-1 regulates neuronal glycogen metabolism and survival. Schulz A, et al. J Cell Biol, 2020 Feb 3. PMID 31968056, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The stress-responsive gene GDPGP1/mcp-1 regulates neuronal glycogen metabolism and survival.
    Title: The stress-responsive gene GDPGP1/mcp-1 regulates neuronal glycogen metabolism and survival.
  2. C15orf58 in humans and C10F3.4 in C. elegans display GDP-hexose phosphorylase activity but the major reaction catalyzed by these enzymes is the phosphorolysis of GDP-D-glucose to GDP and D-glucose 1-phosphate
    Title: A novel GDP-D-glucose phosphorylase involved in quality control of the nucleoside diphosphate sugar pool in Caenorhabditis elegans and mammals.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GDP-D-glucose phosphorylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GDP-D-glucose phosphorylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GDP-D-glucose phosphorylase activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glucose metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GDP-D-glucose phosphorylase 1
NP_001023639.1
  • Confirmed by transcript evidence
NP_001379651.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    5961874..5969173
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001028468.4 → NP_001023639.1  GDP-D-glucose phosphorylase 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023639.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O16879, Q5ZR76
    Conserved Domains (1) summary
    cl14728
    Location:87 → 424
    DUF4922; Domain of unknown function (DUF4922)

  2. NM_001392523.1 → NP_001379651.1  GDP-D-glucose phosphorylase 1 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    cl14728
    Location:63 → 400
    DUF4922; Domain of unknown function (DUF4922)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5ZR76.1

Gene LinkOut

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