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dhs-16 3beta-hydroxysteroid dehydrogenase dhs-16 [ Caenorhabditis elegans ]

Gene ID: 178983, updated on 2-Nov-2024

Summary

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Official Symbol
dhs-16
Official Full Name
3beta-hydroxysteroid dehydrogenase dhs-16
Primary source
WormBase:WBGene00000979
Locus tag
CELE_C10F3.2
See related
AllianceGenome:WB:WBGene00000979
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables steroid dehydrogenase activity. Involved in steroid catabolic process. Predicted to be located in membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in head neurons; hypodermis; tail neurons; and terminal bulb. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 13; fundus albipunctatus; and night blindness. Orthologous to several human genes including DHRS9 (dehydrogenase/reductase 9); HSD17B6 (hydroxysteroid 17-beta dehydrogenase 6); and RDH5 (retinol dehydrogenase 5). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See dhs-16 in Genome Data Viewer
Location:
chromosome: V
Exon count:
3
Sequence:
Chromosome: V; NC_003283.11 (5983745..5985509)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene adenylate cyclase Neighboring gene ncRNA Neighboring gene DUF4789 domain-containing protein Neighboring gene Alpha-(1,6)-fucosyltransferase Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Steroids as central regulators of organismal development and lifespan. Lee SS, et al. PLoS Biol, 2012. PMID 22505849, Free PMC Article
  2. A novel 3-hydroxysteroid dehydrogenase that regulates reproductive development and longevity. Wollam J, et al. PLoS Biol, 2012. PMID 22505847, Free PMC Article
  3. Comparative metabolomics reveals endogenous ligands of DAF-12, a nuclear hormone receptor, regulating C. elegans development and lifespan. Mahanti P, et al. Cell Metab, 2014 Jan 7. PMID 24411940, Free PMC Article
  4. Characterization of the endogenous DAF-12 ligand and its use as an anthelmintic agent in Strongyloides stercoralis. Wang Z, et al. Elife, 2021 Dec 7. PMID 34874004, Free PMC Article
  5. Filarial DAF-12 sense the host serum to resume iL3 development during infection. Bétous R, et al. PLoS Pathog, 2023 Jun. PMID 37339136, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DHS-16 controls DAF-12 activity governing longevity in response to signals from the gonad.
    Title: A novel 3-hydroxysteroid dehydrogenase that regulates reproductive development and longevity.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables steroid dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in steroid catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in steroid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
3beta-hydroxysteroid dehydrogenase dhs-16
NP_504554.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    5983745..5985509
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_072153.8 → NP_504554.1  3beta-hydroxysteroid dehydrogenase dhs-16 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_504554.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O16881
    Conserved Domains (2) summary
    pfam00106
    Location:33 → 228
    adh_short; short chain dehydrogenase
    cl21454
    Location:33 → 319
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O16881.1

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