exp-2 BTB domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: exp-2
Official Full Name: BTB domain-containing protein
Primary source: WormBase:WBGene00001374
Locus tag: CELE_F12F3.1
See related: AllianceGenome:WB:WBGene00001374
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables inward rectifier potassium channel activity. Involved in potassium ion transmembrane transport. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane. Is expressed in intestinal cell; muscle cell; nerve ring; and neurons. Human ortholog(s) of this gene implicated in alcohol dependence; developmental and epileptic encephalopathy 26; and epilepsy. Orthologous to several human genes including KCNF1 (potassium voltage-gated channel modifier subfamily F member 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See exp-2 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 9

Sequence:: Chromosome: V; NC_003283.11 (6139916..6143536)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our results suggest that EXP-2 is a potassium channel with unusual properties that uses a hyperpolarization threshold to activate a regenerative hyperpolarizing current.
Title: CCA-1, EGL-19 and EXP-2 currents shape action potentials in the Caenorhabditis elegans pharynx.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F12F3.1 (e-PCR)
- UniSTS:309704

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables inward rectifier potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables potassium channel activity	IEA Inferred from Electronic Annotation more info
enables potassium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated potassium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IC Inferred by Curator more info	PubMed
part_of voltage-gated potassium channel complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: BTB domain-containing protein

NP_001023792.1

Confirmed by transcript evidence

NP_001367759.1

Confirmed by transcript evidence

NP_001367760.1

Confirmed by transcript evidence

NP_001379872.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

6139916..6143536

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001028621.5 → NP_001023792.1 BTB domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023792.1

Status: REVIEWED

UniProtKB/TrEMBL

H2KZQ7

Conserved Domains (4) summary

smart00225
Location:70 → 170

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00520
Location:281 → 469

Ion_trans; Ion transport protein

pfam02214
Location:70 → 169

BTB_2; BTB/POZ domain

pfam07885
Location:390 → 471

Ion_trans_2; Ion channel
NM_001380662.1 → NP_001367759.1 BTB domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q5WRQ6
NM_001380661.1 → NP_001367760.1 BTB domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

H2KZQ6
NM_001392526.1 → NP_001379872.1 BTB domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

P91256

Conserved Domains (2) summary

pfam00520
Location:251 → 437

Ion_trans; Ion transport protein

pfam02214
Location:38 → 137

BTB_2; BTB/POZ domain