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rme-1 Dynamin-type G domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 179010, updated on 2-Nov-2024

Summary

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Official Symbol
rme-1
Official Full Name
Dynamin-type G domain-containing protein
Primary source
WormBase:WBGene00004373
Locus tag
CELE_W06H8.1
See related
AllianceGenome:WB:WBGene00004373
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables ATP hydrolysis activity and protein domain specific binding activity. Involved in several processes, including endocytic recycling; lipid tube assembly involved in organelle fission; and necroptotic process. Located in recycling endosome membrane. Is expressed in coelomocyte; germ line; gonad; intestine; and pharynx. Orthologous to several human genes including EHD1 (EH domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rme-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
12
Sequence:
Chromosome: V; NC_003283.11 (6208885..6217664)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene Seven TM Receptor Neighboring gene ncRNA Neighboring gene BHLH domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of vacuoles containing extraintestinal differentiated forms of Legionella pneumophila in colonized Caenorhabditis elegans soil nematodes. Hellinga JR, et al. Microbiologyopen, 2015 Aug. PMID 26131925, Free PMC Article
  2. Multicolor bleach-rate imaging enlightens in vivo sterol transport. Wüstner D, et al. Commun Integr Biol, 2010 Jul. PMID 20798830, Free PMC Article
  3. Evidence that RME-1, a conserved C. elegans EH-domain protein, functions in endocytic recycling. Grant B, et al. Nat Cell Biol, 2001 Jun. PMID 11389442
  4. Round-trip ticket: recycling to the plasma membrane requires RME-1. Wendland B. Nat Cell Biol, 2001 Jun. PMID 11389449
  5. GTP-stimulated membrane fission by the N-BAR protein AMPH-1. Kustigian L, et al. Traffic, 2023 Jan. PMID 36435193, Free PMC Article

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytic recycling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid tube assembly involved in organelle fission IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in necroptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of establishment of protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endomembrane system IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in recycling endosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in recycling endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in recycling endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Dynamin-type G domain-containing protein
NP_001024194.1
  • Confirmed by transcript evidence
NP_001024195.1
  • Confirmed by transcript evidence
NP_001024196.1
  • Confirmed by transcript evidence
NP_001343865.1
  • Confirmed by transcript evidence
NP_001343866.1
  • Confirmed by transcript evidence
NP_001343867.1
  • Confirmed by transcript evidence
NP_001367910.1
  • Confirmed by transcript evidence
NP_001379996.1
  • Confirmed by transcript evidence
NP_001379997.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    6208885..6217664
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001029023.4 → NP_001024194.1  Dynamin-type G domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024194.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EEU7
    Conserved Domains (4) summary
    smart00027
    Location:481 → 574
    EH; Eps15 homology domain
    cd09913
    Location:94 → 334
    EHD; Eps15 homology domain (EHD), C-terminal domain
    cd00052
    Location:492 → 556
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam16880
    Location:58 → 90
    EHD_N; N-terminal EH-domain containing protein

  2. NM_001029025.7 → NP_001024196.1  Dynamin-type G domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024196.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8WSP1
    Conserved Domains (4) summary
    smart00027
    Location:505 → 598
    EH; Eps15 homology domain
    cd09913
    Location:118 → 358
    EHD; Eps15 homology domain (EHD), C-terminal domain
    cd00052
    Location:516 → 580
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam16880
    Location:82 → 114
    EHD_N; N-terminal EH-domain containing protein

  3. NM_001392527.1 → NP_001379996.1  Dynamin-type G domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KFZ3, Q9N5B7
    Conserved Domains (4) summary
    smart00027
    Location:678 → 771
    EH; Eps15 homology domain
    cd09913
    Location:291 → 531
    EHD; Eps15 homology domain (EHD), C-terminal domain
    pfam16880
    Location:255 → 287
    EHD_N; N-terminal EH-domain containing protein
    pfam18150
    Location:519 → 625
    DUF5600; Domain of unknown function (DUF5600)

  4. NM_001380664.2 → NP_001367910.1  Dynamin-type G domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5ECC3, Q7KFZ3
    Conserved Domains (4) summary
    smart00027
    Location:683 → 776
    EH; Eps15 homology domain
    cd09913
    Location:291 → 531
    EHD; Eps15 homology domain (EHD), C-terminal domain
    pfam16880
    Location:255 → 287
    EHD_N; N-terminal EH-domain containing protein
    pfam18150
    Location:519 → 625
    DUF5600; Domain of unknown function (DUF5600)

  5. NM_001356657.3 → NP_001343865.1  Dynamin-type G domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2C9C3Z4
    Conserved Domains (3) summary
    smart00027
    Location:505 → 598
    EH; Eps15 homology domain
    cd09913
    Location:113 → 353
    EHD; Eps15 homology domain (EHD), C-terminal domain
    pfam16880
    Location:78 → 109
    EHD_N; N-terminal EH-domain containing protein

  6. NM_001356658.3 → NP_001343866.1  Dynamin-type G domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2C9C3S7
    Conserved Domains (3) summary
    smart00027
    Location:500 → 593
    EH; Eps15 homology domain
    cd09913
    Location:113 → 353
    EHD; Eps15 homology domain (EHD), C-terminal domain
    pfam16880
    Location:78 → 109
    EHD_N; N-terminal EH-domain containing protein

  7. NM_001029024.5 → NP_001024195.1  Dynamin-type G domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024195.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EFP1
    Conserved Domains (4) summary
    smart00027
    Location:468 → 561
    EH; Eps15 homology domain
    cd09913
    Location:76 → 316
    EHD; Eps15 homology domain (EHD), C-terminal domain
    cd00052
    Location:479 → 543
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam16880
    Location:40 → 72
    EHD_N; N-terminal EH-domain containing protein

  8. NM_001356659.4 → NP_001343867.1  Dynamin-type G domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2C9C352
    Conserved Domains (3) summary
    smart00027
    Location:452 → 545
    EH; Eps15 homology domain
    cd09913
    Location:60 → 300
    EHD; Eps15 homology domain (EHD), C-terminal domain
    pfam16880
    Location:25 → 56
    EHD_N; N-terminal EH-domain containing protein

  9. NM_001392528.1 → NP_001379997.1  Dynamin-type G domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86S80
    Conserved Domains (4) summary
    smart00027
    Location:447 → 540
    EH; Eps15 homology domain
    cd09913
    Location:60 → 300
    EHD; Eps15 homology domain (EHD), C-terminal domain
    pfam16880
    Location:24 → 56
    EHD_N; N-terminal EH-domain containing protein
    pfam18150
    Location:288 → 394
    DUF5600; Domain of unknown function (DUF5600)
Nucleotide Protein
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