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bcl-11 C2H2-type domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 179019, updated on 2-Nov-2024

Summary

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Official Symbol
bcl-11
Official Full Name
C2H2-type domain-containing protein
Primary source
WormBase:WBGene00017430
Locus tag
CELE_F13H6.1
See related
AllianceGenome:WB:WBGene00017430
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in head; hypodermis; muscle cell; neurons; and pharynx. Human ortholog(s) of this gene implicated in autism spectrum disorder; beta thalassemia; immunodeficiency 49; schizophrenia; and sickle cell anemia. Orthologous to human BCL11A (BCL11 transcription factor A) and BCL11B (BCL11 transcription factor B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See bcl-11 in Genome Data Viewer
Location:
chromosome: V
Exon count:
13
Sequence:
Chromosome: V; NC_003283.11 (6356025..6362997)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Esterase CM06B1 Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. C. elegans molting requires rhythmic accumulation of the Grainyhead/LSF transcription factor GRH-1. Meeuse MWM, et al. EMBO J, 2023 Feb 15. PMID 36688410, Free PMC Article
  2. A whole-genome RNAi Screen for C. elegans miRNA pathway genes. Parry DH, et al. Curr Biol, 2007 Dec 4. PMID 18023351, Free PMC Article
  3. A 4D single-cell protein atlas of transcription factors delineates spatiotemporal patterning during embryogenesis. Ma X, et al. Nat Methods, 2021 Aug. PMID 34312566
  4. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
C2H2-type domain-containing protein
NP_001122913.1
  • Confirmed by transcript evidence
NP_504620.2
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    6356025..6362997
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001129441.4 → NP_001122913.1  C2H2-type domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122913.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A9D4E4
    Conserved Domains (3) summary
    sd00017
    Location:500 → 520
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:499 → 520
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:512 → 537
    zf-H2C2_2; Zinc-finger double domain

  2. NM_072219.9 → NP_504620.2  C2H2-type domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_504620.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KZR6
    Conserved Domains (4) summary
    sd00017
    Location:496 → 516
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:495 → 516
    zf-C2H2; Zinc finger, C2H2 type
    pfam12756
    Location:496 → 573
    zf-C2H2_2; C2H2 type zinc-finger (2 copies)
    pfam13465
    Location:508 → 533
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein
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