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erfa-1 Eukaryotic peptide chain release factor subunit 1 [ Caenorhabditis elegans ]

Gene ID: 179028, updated on 2-Nov-2024

Summary

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Official Symbol
erfa-1
Official Full Name
Eukaryotic peptide chain release factor subunit 1
Primary source
WormBase:WBGene00020269
Locus tag
CELE_T05H4.6
See related
AllianceGenome:WB:WBGene00020269
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable sequence-specific mRNA binding activity and translation release factor activity, codon specific. Predicted to be involved in cytoplasmic translational termination. Predicted to be located in cytoplasm. Predicted to be part of translation release factor complex. Predicted to be active in cytosol. Orthologous to human ETF1 (eukaryotic translation termination factor 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See erfa-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
6
Sequence:
Chromosome: V; NC_003283.11 (6434130..6436402)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Aldehyde dehydrogenase Neighboring gene Gastrulation defective protein 1 Neighboring gene NADH-cytochrome b5 reductase Neighboring gene NADH-cytochrome b5 reductase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Proteomic analysis of Caenorhabditis elegans. Jeong PY, et al. Methods Mol Biol, 2009. PMID 19381582
  2. A genomewide RNAi screen for genes that affect the stability, distribution and function of P granules in Caenorhabditis elegans. Updike DL, et al. Genetics, 2009 Dec. PMID 19805813, Free PMC Article
  3. ABCE1 is a highly conserved RNA silencing suppressor. Kärblane K, et al. PLoS One, 2015. PMID 25659154, Free PMC Article
  4. CCAR-1 works together with the U2AF large subunit UAF-1 to regulate alternative splicing. Lugano DI, et al. RNA Biol, 2024 Jan. PMID 38126797, Free PMC Article
  5. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables sequence-specific mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation release factor activity IEA
Inferred from Electronic Annotation
more info
  
enables translation release factor activity, codon specific IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translational termination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational termination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of translation release factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Eukaryotic peptide chain release factor subunit 1
NP_001343671.1
  • Confirmed by transcript evidence
NP_001380133.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    6434130..6436402
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001356664.2 → NP_001343671.1  Eukaryotic peptide chain release factor subunit 1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O16520, S6EZT6
    Conserved Domains (1) summary
    COG1503
    Location:19 → 426
    eRF1; Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]

  2. NM_001392531.1 → NP_001380133.1  Eukaryotic peptide chain release factor subunit 1 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    COG1503
    Location:19 → 426
    eRF1; Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O16520.3

Gene LinkOut

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