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acl-8 Phospholipid/glycerol acyltransferase domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 179031, updated on 2-Nov-2024

Summary

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Official Symbol
acl-8
Official Full Name
Phospholipid/glycerol acyltransferase domain-containing protein
Primary source
WormBase:WBGene00020264
Locus tag
CELE_T05H4.1
See related
AllianceGenome:WB:WBGene00020264
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable acyltransferase activity. Predicted to be involved in phosphatidylinositol acyl-chain remodeling. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including anal depressor muscle; intestine; nervous system; pharynx; and reproductive system. Orthologous to human LCLAT1 (lysocardiolipin acyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See acl-8 in Genome Data Viewer
Location:
chromosome: V
Exon count:
6
Sequence:
Chromosome: V; NC_003283.11 (6450870..6453119)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene U2A'/phosphoprotein 32 family A C-terminal domain-containing protein Neighboring gene F-box domain-containing protein Neighboring gene Phospholipid/glycerol acyltransferase domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. LYCAT, a homologue of C. elegans acl-8, acl-9, and acl-10, determines the fatty acid composition of phosphatidylinositol in mice. Imae R, et al. J Lipid Res, 2012 Mar. PMID 22172515, Free PMC Article
  2. Intracellular phospholipase A1 and acyltransferase, which are involved in Caenorhabditis elegans stem cell divisions, determine the sn-1 fatty acyl chain of phosphatidylinositol. Imae R, et al. Mol Biol Cell, 2010 Sep 15. PMID 20668164, Free PMC Article
  3. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
  4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study identified acl-8, -9, and -10, which are closely related to each other, and ipla-1 as strong candidates for genes involved in fatty acid remodeling at the sn-1 position of phosphatidylinositol.
    Title: Intracellular phospholipase A1 and acyltransferase, which are involved in Caenorhabditis elegans stem cell divisions, determine the sn-1 fatty acyl chain of phosphatidylinositol.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in phosphatidylinositol acyl-chain remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Phospholipid/glycerol acyltransferase domain-containing protein
NP_001348648.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    6450870..6453119
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001361761.3 → NP_001348648.1  Phospholipid/glycerol acyltransferase domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    O16526
    Conserved Domains (2) summary
    cd07990
    Location:55 → 250
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:236 → 313
    Acyltransf_C; Acyltransferase C-terminus
Nucleotide Protein
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