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lec-10 Galectin [ Caenorhabditis elegans ]

Gene ID: 179034, updated on 2-Nov-2024

Summary

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Official Symbol
lec-10
Official Full Name
Galectin
Primary source
WormBase:WBGene00002273
Locus tag
CELE_W01A11.4
See related
AllianceGenome:WB:WBGene00002273
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables glycolipid binding activity. Located in apical part of cell and cytoplasm. Is expressed in intestine. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See lec-10 in Genome Data Viewer
Location:
chromosome: V
Exon count:
3
Sequence:
Chromosome: V; NC_003283.11 (6488203..6489120, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene KASH domain-containing protein;Nuclear migration protein unc-83 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Choline/carnitine acyltransferase domain-containing protein Neighboring gene ncRNA Neighboring gene Acyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Visual detection of isothermal nucleic acid amplification using pH-sensitive dyes. Tanner NA, et al. Biotechniques, 2015 Feb. PMID 25652028
  2. Nanoparticles To Study Lectins in Caenorhabditis elegans: Multivalent Galactose β1-4 Fucose-Functionalized Dendrimers Provide Protection from Oxidative Stress. VanKoten HW, et al. Biomacromolecules, 2021 Nov 8. PMID 34704753, Free PMC Article
  3. Deletion of lec-10, a galectin-encoding gene, increases susceptibility to oxidative stress in Caenorhabditis elegans. Nemoto-Sasaki Y, et al. Biol Pharm Bull, 2009 Dec. PMID 19952414
  4. Caenorhabditis elegans galectins LEC-6 and LEC-10 interact with similar glycoconjugates in the intestine. Maduzia LL, et al. J Biol Chem, 2011 Feb 11. PMID 21115491, Free PMC Article
  5. Caenorhabditis elegans galectins LEC-1-LEC-11: structural features and sugar-binding properties. Nemoto-Sasaki Y, et al. Biochim Biophys Acta, 2008 Oct. PMID 18675319

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. a model where LEC-6 and LEC-10 interact with glycoproteins through specific glycans to regulate their cellular fate.
    Title: Caenorhabditis elegans galectins LEC-6 and LEC-10 interact with similar glycoconjugates in the intestine.
  2. results suggest that the deletion of lec-10 does not have a notable effect on the worm's survival under laboratory conditions. However, this study indicates that lec-10 does confer some protection against oxidative stress.
    Title: Deletion of lec-10, a galectin-encoding gene, increases susceptibility to oxidative stress in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables carbohydrate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables galactoside binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycolipid binding IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in apical part of cell IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Galectin
NP_504647.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    6488203..6489120 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_072246.10 → NP_504647.1  Galectin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_504647.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EBV4
    Conserved Domains (1) summary
    smart00276
    Location:13 → 138
    GLECT; Galectin
Nucleotide Protein
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