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cpt-6 Choline/carnitine acyltransferase domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 179035, updated on 2-Nov-2024

Summary

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Official Symbol
cpt-6
Official Full Name
Choline/carnitine acyltransferase domain-containing protein
Primary source
WormBase:WBGene00020911
Locus tag
CELE_W01A11.5
See related
AllianceGenome:WB:WBGene00020911
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable carnitine O-palmitoyltransferase activity. Predicted to be involved in carnitine metabolic process and fatty acid metabolic process. Predicted to be active in mitochondrion. Is expressed in hypodermis. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cpt-6 in Genome Data Viewer
Location:
chromosome: V
Exon count:
8
Sequence:
Chromosome: V; NC_003283.11 (6490086..6493921, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene KASH domain-containing protein;Nuclear migration protein unc-83 Neighboring gene ncRNA Neighboring gene Galectin Neighboring gene ncRNA Neighboring gene Acyltransferase Neighboring gene Epoxide hydrolase;Microsomal epoxide hydrolase Neighboring gene molybdopterin molybdotransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Serotonin regulates C. elegans fat and feeding through independent molecular mechanisms. Srinivasan S, et al. Cell Metab, 2008 Jun. PMID 18522834, Free PMC Article
  2. Evolutionary analysis of the carnitine- and choline acyltransferases suggests distinct evolution of CPT2 versus CPT1 and related variants. van der Hoek MD, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2018 Aug. PMID 29730527
  3. A quantitative genome-wide RNAi screen in C. elegans for antifungal innate immunity genes. Zugasti O, et al. BMC Biol, 2016 Apr 29. PMID 27129311, Free PMC Article
  4. Fatty acid desaturation and the regulation of adiposity in Caenorhabditis elegans. Brock TJ, et al. Genetics, 2007 Jun. PMID 17435249, Free PMC Article
  5. A Caenorhabditis elegans nutrient response system partially dependent on nuclear receptor NHR-49. Van Gilst MR, et al. Proc Natl Acad Sci U S A, 2005 Sep 20. PMID 16157872, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables carnitine O-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in carnitine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Choline/carnitine acyltransferase domain-containing protein
NP_504648.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    6490086..6493921 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_072247.7 → NP_504648.1  Choline/carnitine acyltransferase domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_504648.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q23066
    Conserved Domains (1) summary
    pfam00755
    Location:148 → 741
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
Nucleotide Protein
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