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mtl-1 Metallothionein-1 [ Caenorhabditis elegans ]

Gene ID: 179060, updated on 2-Nov-2024

Summary

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Official Symbol
mtl-1
Official Full Name
Metallothionein-1
Primary source
WormBase:WBGene00003473
Locus tag
CELE_K11G9.6
See related
AllianceGenome:WB:WBGene00003473
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables cadmium ion binding activity and zinc ion binding activity. Involved in several processes, including response to cadmium ion; response to lead ion; and response to mercury ion. Predicted to be located in cytoplasm. Is expressed in intestine and pharynx. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mtl-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
2
Sequence:
Chromosome: V; NC_003283.11 (6691371..6691863, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene ncRNA Neighboring gene Metallothionein Neighboring gene Alkaline ceramidase Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nutritive Manganese and Zinc Overdosing in Aging C. elegans Result in a Metallothionein-Mediated Alteration in Metal Homeostasis. Baesler J, et al. Mol Nutr Food Res, 2021 Apr. PMID 33641237, Free PMC Article
  2. Caenorhabditis elegans metallothioneins protect against toxicity induced by depleted uranium. Jiang GC, et al. Toxicol Sci, 2009 Oct. PMID 19617453
  3. Nematode and snail metallothioneins. Höckner M, et al. J Biol Inorg Chem, 2011 Oct. PMID 21822727
  4. Trans-generational effects of copper on nerve damage in Caenorhabditis elegans. Zhang Y, et al. Chemosphere, 2021 Dec. PMID 34225113
  5. Metallothioneins are required for formation of cross-adaptation response to neurobehavioral toxicity from lead and mercury exposure in nematodes. Ye B, et al. PLoS One, 2010 Nov 18. PMID 21124968, Free PMC Article

See all (79) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that the defects of adaptive response to neurobehavioral toxicity induced by metal exposure formed in mtl-1 and mtl-2 mutants could be completely rescued by the expression of mtl-1 and mtl-2 with the aid of their native promoters.
    Title: Metallothioneins are required for formation of cross-adaptation response to neurobehavioral toxicity from lead and mercury exposure in nematodes.
  2. Caenorhabditis elegans metallothionein isoform specificity--metal binding abilities and the role of histidine in CeMT1
    Title: Caenorhabditis elegans metallothionein isoform specificity--metal binding abilities and the role of histidine in CeMT1 and CeMT2.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables cadmium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cadmium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables copper ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to metal ion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to cadmium ion IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to heat IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to lead ion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to mercury ion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
Metallothionein-1
NP_504696.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    6691371..6691863 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_072295.6 → NP_504696.1  Metallothionein-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_504696.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P17511
    Conserved Domains (1) summary
    pfam12785
    Location:3 → 66
    VESA1_N; Variant erythrocyte surface antigen-1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P17511.2

Gene LinkOut

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