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tofu-2 Schlafen-like protein 2 [ Caenorhabditis elegans ]

Gene ID: 179089, updated on 2-Nov-2024

Summary

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Official Symbol
tofu-2
Official Full Name
Schlafen-like protein 2
Primary source
WormBase:WBGene00017620
Locus tag
CELE_F20A1.9
See related
AllianceGenome:WB:WBGene00017620
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables RNA endonuclease activity. Involved in primary piRNA processing. Located in cytoplasm. Part of endoribonuclease complex. Is expressed in germ line. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See tofu-2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
8
Sequence:
Chromosome: V; NC_003283.11 (7049434..7051248, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene Secreted protein Neighboring gene Secreted protein Neighboring gene transcellular chaperone signaling (x)cross tissue

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. piRNA processing by a trimeric Schlafen-domain nuclease. Podvalnaya N, et al. Nature, 2023 Oct. PMID 37758951, Free PMC Article
  2. Functional Proteomics Identifies a PICS Complex Required for piRNA Maturation and Chromosome Segregation. Zeng C, et al. Cell Rep, 2019 Jun 18. PMID 31216475
  3. A genome-wide RNAi screen identifies factors required for distinct stages of C. elegans piRNA biogenesis. Goh WS, et al. Genes Dev, 2014 Apr 1. PMID 24696458, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA endonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in primary piRNA processing IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of endoribonuclease complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Schlafen-like protein 2
NP_504786.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    7049434..7051248 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_072385.7 → NP_504786.2  Schlafen-like protein 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_504786.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q19614
    Conserved Domains (2) summary
    cd12873
    Location:11 → 167
    SPRY_DDX1; SPRY domain associated with DEAD box gene DDX1
    pfam04326
    Location:231 → 322
    AlbA_2; Putative DNA-binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q19614.3

Gene LinkOut

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