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mdt-6 Mediator of RNA polymerase II transcription subunit 6 [ Caenorhabditis elegans ]

Gene ID: 179091, updated on 2-Nov-2024

Summary

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Official Symbol
mdt-6
Official Full Name
Mediator of RNA polymerase II transcription subunit 6
Primary source
WormBase:WBGene00003164
Locus tag
CELE_Y57E12AL.5
See related
AllianceGenome:WB:WBGene00003164
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable transcription coactivator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of core mediator complex and mediator complex. Is expressed in excretory cell; intestine; and pharynx. Orthologous to human MED6 (mediator complex subunit 6). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mdt-6 in Genome Data Viewer
Location:
chromosome: V
Exon count:
3
Sequence:
Chromosome: V; NC_003283.11 (7058547..7059624, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene DUF4148 domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Serine incorporator 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The MED-7 transcriptional mediator encoded by let-49 is required for gonad and germ cell development in Caenorhabditis elegans. Kwon JY, et al. FEBS Lett, 2001 Nov 23. PMID 11728440
  2. The nematode homologue of Mediator complex subunit 28, F28F8.5, is a critical regulator of C. elegans development. Kostrouchová M, et al. PeerJ, 2017. PMID 28603670, Free PMC Article
  3. The Mediator subunit MDT-15 confers metabolic adaptation to ingested material. Taubert S, et al. PLoS Genet, 2008 Feb 29. PMID 18454197, Free PMC Article
  4. Proteomic Interactome of C. elegans Mediator Complex Subunit 28 (MDT-28) Reveals Predominant Association with a Restricted Set of Core Mediator Subunits and an Affinity to Additional Structural and Enzymatic Proteins. Yilma P, et al. Folia Biol (Praha), 2019. PMID 32362303
  5. Components of the transcriptional Mediator complex are required for asymmetric cell division in C. elegans. Yoda A, et al. Development, 2005 Apr. PMID 15790964

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of core mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mediator of RNA polymerase II transcription subunit 6
NP_504791.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    7058547..7059624 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_072390.7 → NP_504791.3  Mediator of RNA polymerase II transcription subunit 6 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_504791.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O18534, Q9N337
    Conserved Domains (1) summary
    pfam04934
    Location:19 → 149
    Med6; MED6 mediator sub complex component
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9N337.1

Gene LinkOut

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