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fkb-3 peptidylprolyl isomerase [ Caenorhabditis elegans ]

Gene ID: 179113, updated on 2-Nov-2024

Summary

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Official Symbol
fkb-3
Official Full Name
peptidylprolyl isomerase
Primary source
WormBase:WBGene00001428
Locus tag
CELE_C05C8.3
See related
AllianceGenome:WB:WBGene00001428
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Predicted to be active in endoplasmic reticulum. Is expressed in hypodermis. Orthologous to human FKBP9 (FKBP prolyl isomerase 9). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See fkb-3 in Genome Data Viewer
Location:
chromosome: V
Exon count:
2
Sequence:
Chromosome: V; NC_003283.11 (7225223..7226320)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene KxDL domain-containing protein Neighboring gene CCHC-type domain-containing protein Neighboring gene 50S ribosomal protein L6 Neighboring gene ncRNA Neighboring gene GEX Interacting protein Neighboring gene KRR1 small subunit processome component Neighboring gene Exonuclease domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Loss of secretory pathway FK506-binding proteins results in cold-sensitive lethality and associate extracellular matrix defects in the nematode Caenorhabditis elegans. Winter AD, et al. J Biol Chem, 2007 Apr 27. PMID 17339317
  2. Sequence diversification of the FK506-binding proteins in several different genomes. Galat A. Eur J Biochem, 2000 Aug. PMID 10931176
  3. DAF-16-dependent and independent expression targets of DAF-2 insulin receptor-like pathway in Caenorhabditis elegans include FKBPs. Yu H, et al. J Mol Biol, 2001 Dec 14. PMID 11743719
  4. Identification and comparative analysis of the peptidyl-prolyl cis/trans isomerase repertoires of H. sapiens, D. melanogaster, C. elegans, S. cerevisiae and Sz. pombe. Pemberton TJ, et al. Comp Funct Genomics, 2005. PMID 18629211, Free PMC Article
  5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
peptidylprolyl isomerase
NP_001379619.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    7225223..7226320
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392544.1 → NP_001379619.1  peptidylprolyl isomerase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    O16309
    Conserved Domains (2) summary
    COG0545
    Location:55 → 250
    FkpA; FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones]
    pfam00254
    Location:159 → 250
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
Nucleotide Protein
Heading Accession and Version

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