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xpo-1 Exportin-1 C-terminal domain-containing protein;Importin N-terminal domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 179160, updated on 2-Nov-2024

Summary

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Official Symbol
xpo-1
Official Full Name
Exportin-1 C-terminal domain-containing protein;Importin N-terminal domain-containing protein
Primary source
WormBase:WBGene00002078
Locus tag
CELE_ZK742.1
See related
AllianceGenome:WB:WBGene00002078
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable nuclear export signal receptor activity. Predicted to be involved in ribosomal large subunit export from nucleus and ribosomal small subunit export from nucleus. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in colorectal cancer; gastric adenocarcinoma; hepatocellular carcinoma; and lung non-small cell carcinoma. Orthologous to human XPO1 (exportin 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See xpo-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
8
Sequence:
Chromosome: V; NC_003283.11 (7805064..7814584)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene UV-stimulated scaffold protein A homolog Neighboring gene ncRNA Neighboring gene NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein Neighboring gene NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Fatty acid-binding protein homolog 4 Neighboring gene Papilin Neighboring gene EGF-like domain-containing protein Neighboring gene Transthyretin-like protein 33

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Autoregulation of microRNA biogenesis by let-7 and Argonaute. Zisoulis DG, et al. Nature, 2012 Jun 28. PMID 22722835, Free PMC Article
  2. Nuclear Export Inhibition Enhances HLH-30/TFEB Activity, Autophagy, and Lifespan. Silvestrini MJ, et al. Cell Rep, 2018 May 15. PMID 29768192, Free PMC Article
  3. Exportin 1 modulates life span by regulating nucleolar dynamics via the autophagy protein LGG-1/GABARAP. Kumar AV, et al. Sci Adv, 2022 Apr. PMID 35363528, Free PMC Article
  4. The germ cell-specific TAP-like protein NXF-2 forms a novel granular structure and is required for tra-2 3'UTR-dependent mRNA export in Caenorhabditis elegans. Miwa T, et al. Genes Cells, 2022 Oct. PMID 35950937
  5. Evolutionary and transcriptional analysis of karyopherin beta superfamily proteins. Quan Y, et al. Mol Cell Proteomics, 2008 Jul. PMID 18353765, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables nuclear export signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear export signal receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein export from nucleus IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosomal large subunit export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal small subunit export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Exportin-1 C-terminal domain-containing protein;Importin N-terminal domain-containing protein
NP_001367571.1
  • Confirmed by transcript evidence
NP_741567.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    7805064..7814584
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171484.8 → NP_741567.1  Importin N-terminal domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741567.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q23089
    Conserved Domains (1) summary
    COG5101
    Location:22 → 1062
    CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]

  2. NM_001380696.1 → NP_001367571.1  Exportin-1 C-terminal domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MPS6
    Conserved Domains (1) summary
    cl07396
    Location:1 → 39
    CRM1_C; CRM1 C terminal
Nucleotide Protein
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