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nipi-4 Protein nipi-4 [ Caenorhabditis elegans ]

Gene ID: 179167, updated on 2-Nov-2024

Summary

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Official Symbol
nipi-4
Official Full Name
Protein nipi-4
Primary source
WormBase:WBGene00077712
Locus tag
CELE_F40A3.5
See related
AllianceGenome:WB:WBGene00077712
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATP binding activity and protein kinase activity. Involved in defense response to fungus; positive regulation of gene expression; and response to wounding. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in hypodermis. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nipi-4 in Genome Data Viewer
Location:
chromosome: V
Exon count:
9
Sequence:
Chromosome: V; NC_003283.11 (7868461..7870807, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene SLBB domain-containing protein Neighboring gene DUF2975 domain-containing protein Neighboring gene Envelope glycoprotein N Neighboring gene Phosphatidylethanolamine-binding protein;Phosphatidylethanolamine-binding protein homolog F40A3.3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The pseudokinase NIPI-4 is a novel regulator of antimicrobial peptide gene expression. Labed SA, et al. PLoS One, 2012. PMID 22470487, Free PMC Article
  2. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
NOT enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
NOT involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to fungus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in response to wounding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Protein nipi-4
NP_505028.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    7868461..7870807 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_072627.7 → NP_505028.3  Protein nipi-4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505028.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O16262
    Conserved Domains (2) summary
    pfam07714
    Location:87 → 350
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:86 → 350
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O16262.3

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