let-413 PDZ domain-containing protein;Protein lap1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: let-413
Official Full Name: PDZ domain-containing protein;Protein lap1
Primary source: WormBase:WBGene00002632
Locus tag: CELE_F26D11.11
See related: AllianceGenome:WB:WBGene00002632
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in several processes, including adherens junction assembly; embryonic digestive tract morphogenesis; and maintenance of epithelial cell apical/basal polarity. Located in basolateral plasma membrane. Is expressed in epithelial cell; nerve ring; rectum; and spermatheca. Orthologous to human SCRIB (scribble planar cell polarity protein). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See let-413 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 9

Sequence:: Chromosome: V; NC_003283.11 (7973078..7977776, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LET-413 is required for DENN-4-mediated RAB-10 activation, and the LET-413-assisted RAB-5 to RAB-10 cascade contributes to the integrity of C. elegans intestinal epithelia.
Title: LET-413/Erbin acts as a RAB-5 effector to promote RAB-10 activation during endocytic recycling.
requirement for LET-413 and DLG-1 in the polarization of the spermathecal cells
Title: Increased IP3/Ca2+ signaling compensates depletion of LET-413/DLG-1 in C. elegans epithelial junction assembly.
These results represent the first in vivo analysis of requirements for the L27 domain of a Discs-large/SAP97 protein, identify a crucial LET-413/Scribble regulatory motif.
Title: Dynamic analysis identifies novel roles for DLG-1 subdomains in AJM-1 recruitment and LET-413-dependent apical focusing.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F26D11.11 (e-PCR)
- UniSTS:312302

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Process	Evidence Code	Pubs
involved_in actin filament-based process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adherens junction assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-cell junction assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic digestive tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of cell polarity	IEP Inferred from Expression Pattern more info	PubMed
involved_in maintenance of epithelial cell apical/basal polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of intermediate filament polymerization or depolymerization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: PDZ domain-containing protein;Protein lap1

NP_001023851.1

Confirmed by transcript evidence

NP_001362012.1

Confirmed by transcript evidence

NP_001362181.1

Confirmed by transcript evidence

NP_001362182.1

Confirmed by transcript evidence

NP_001362183.1

Confirmed by transcript evidence

NP_001362184.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

7973078..7977776 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001374916.3 → NP_001362181.1 PDZ domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A5K1IC26

Conserved Domains (3) summary

PLN00113
Location:14 → 370

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

cd00992
Location:574 → 661

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:38 → 60

LRR_RI; leucine-rich repeat [structural motif]
NM_001028680.7 → NP_001023851.1 Protein lap1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023851.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O61967, Q6A580, Q9NFN7

Conserved Domains (5) summary

COG0265
Location:590 → 659

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

cd00116
Location:37 → 349

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd00992
Location:567 → 654

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:38 → 60

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:59 → 117

LRR_8; Leucine rich repeat
NM_001374915.3 → NP_001362182.1 PDZ domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A5K1IAV7

Conserved Domains (3) summary

PLN00113
Location:14 → 370

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

cd00992
Location:574 → 652

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:38 → 60

LRR_RI; leucine-rich repeat [structural motif]
NM_001374914.3 → NP_001362183.1 PDZ domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A5K1I804

Conserved Domains (3) summary

PLN00113
Location:14 → 370

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

cd00992
Location:567 → 645

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:38 → 60

LRR_RI; leucine-rich repeat [structural motif]
NM_001374918.2 → NP_001362012.1 Protein lap1 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (3) summary

PLN00113
Location:14 → 370

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

cd00992
Location:574 → 661

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:38 → 60

LRR_RI; leucine-rich repeat [structural motif]
NM_001374917.4 → NP_001362184.1 PDZ domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A5K1I8A6

Conserved Domains (3) summary

PLN00113
Location:14 → 370

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

cd00992
Location:567 → 654

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:38 → 60

LRR_RI; leucine-rich repeat [structural motif]