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let-413 PDZ domain-containing protein;Protein lap1 [ Caenorhabditis elegans ]

Gene ID: 179171, updated on 18-Sep-2024

Summary

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Official Symbol
let-413
Official Full Name
PDZ domain-containing protein;Protein lap1
Primary source
WormBase:WBGene00002632
Locus tag
CELE_F26D11.11
See related
AllianceGenome:WB:WBGene00002632
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in several processes, including adherens junction assembly; embryonic digestive tract morphogenesis; and maintenance of epithelial cell apical/basal polarity. Located in basolateral plasma membrane. Is expressed in epithelial cell; nerve ring; rectum; and spermatheca. Orthologous to several human genes including SCRIB (scribble planar cell polarity protein). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See let-413 in Genome Data Viewer
Location:
chromosome: V
Exon count:
9
Sequence:
Chromosome: V; NC_003283.11 (7973078..7977776, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Innexin Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Basolateral targeting by leucine-rich repeat domains in epithelial cells. Legouis R, et al. EMBO Rep, 2003 Nov. PMID 14578922, Free PMC Article
  2. Assembly of C. elegans apical junctions involves positioning and compaction by LET-413 and protein aggregation by the MAGUK protein DLG-1. McMahon L, et al. J Cell Sci, 2001 Jun. PMID 11493666
  3. Dynamic analysis identifies novel roles for DLG-1 subdomains in AJM-1 recruitment and LET-413-dependent apical focusing. Lockwood CA, et al. J Cell Sci, 2008 May 1. PMID 18411252, Free PMC Article
  4. Cooperative regulation of AJM-1 controls junctional integrity in Caenorhabditis elegans epithelia. Köppen M, et al. Nat Cell Biol, 2001 Nov. PMID 11715019
  5. LET-413 is a basolateral protein required for the assembly of adherens junctions in Caenorhabditis elegans. Legouis R, et al. Nat Cell Biol, 2000 Jul. PMID 10878806

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LET-413 is required for DENN-4-mediated RAB-10 activation, and the LET-413-assisted RAB-5 to RAB-10 cascade contributes to the integrity of C. elegans intestinal epithelia.
    Title: LET-413/Erbin acts as a RAB-5 effector to promote RAB-10 activation during endocytic recycling.
  2. requirement for LET-413 and DLG-1 in the polarization of the spermathecal cells
    Title: Increased IP3/Ca2+ signaling compensates depletion of LET-413/DLG-1 in C. elegans epithelial junction assembly.
  3. These results represent the first in vivo analysis of requirements for the L27 domain of a Discs-large/SAP97 protein, identify a crucial LET-413/Scribble regulatory motif.
    Title: Dynamic analysis identifies novel roles for DLG-1 subdomains in AJM-1 recruitment and LET-413-dependent apical focusing.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in actin filament-based process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in adherens junction assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell-cell junction assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryonic digestive tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment or maintenance of cell polarity IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in maintenance of epithelial cell apical/basal polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in regulation of intermediate filament polymerization or depolymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
PDZ domain-containing protein;Protein lap1
NP_001023851.1
  • Confirmed by transcript evidence
NP_001362012.1
  • Confirmed by transcript evidence
NP_001362181.1
  • Confirmed by transcript evidence
NP_001362182.1
  • Confirmed by transcript evidence
NP_001362183.1
  • Confirmed by transcript evidence
NP_001362184.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    7973078..7977776 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001374916.3 → NP_001362181.1  PDZ domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5K1IC26
    Conserved Domains (3) summary
    PLN00113
    Location:14 → 370
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    cd00992
    Location:574 → 661
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00033
    Location:38 → 60
    LRR_RI; leucine-rich repeat [structural motif]

  2. NM_001028680.7 → NP_001023851.1  Protein lap1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023851.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O61967, Q6A580, Q9NFN7
    Conserved Domains (5) summary
    COG0265
    Location:590 → 659
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00116
    Location:37 → 349
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    cd00992
    Location:567 → 654
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00033
    Location:38 → 60
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:59 → 117
    LRR_8; Leucine rich repeat

  3. NM_001374915.3 → NP_001362182.1  PDZ domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5K1IAV7
    Conserved Domains (3) summary
    PLN00113
    Location:14 → 370
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    cd00992
    Location:574 → 652
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00033
    Location:38 → 60
    LRR_RI; leucine-rich repeat [structural motif]

  4. NM_001374914.3 → NP_001362183.1  PDZ domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5K1I804
    Conserved Domains (3) summary
    PLN00113
    Location:14 → 370
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    cd00992
    Location:567 → 645
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00033
    Location:38 → 60
    LRR_RI; leucine-rich repeat [structural motif]

  5. NM_001374918.2 → NP_001362012.1  Protein lap1 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (3) summary
    PLN00113
    Location:14 → 370
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    cd00992
    Location:574 → 661
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00033
    Location:38 → 60
    LRR_RI; leucine-rich repeat [structural motif]

  6. NM_001374917.4 → NP_001362184.1  PDZ domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5K1I8A6
    Conserved Domains (3) summary
    PLN00113
    Location:14 → 370
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    cd00992
    Location:567 → 654
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00033
    Location:38 → 60
    LRR_RI; leucine-rich repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O61967.3

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