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abhd-12 Serine aminopeptidase S33 domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 179172, updated on 2-Nov-2024

Summary

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Official Symbol
abhd-12
Official Full Name
Serine aminopeptidase S33 domain-containing protein
Primary source
WormBase:WBGene00022393
Locus tag
CELE_Y97E10AL.2
See related
AllianceGenome:WB:WBGene00022393
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable lysophospholipase activity and monoacylglycerol lipase activity. Predicted to be involved in monoacylglycerol catabolic process and phosphatidylserine catabolic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in PHARC syndrome. Orthologous to several human genes including ABHD12B (abhydrolase domain containing 12B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See abhd-12 in Genome Data Viewer
Location:
chromosome: V
Exon count:
7
Sequence:
Chromosome: V; NC_003283.11 (7983879..7985954)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Gluconokinase Neighboring gene N-alpha-acetyltransferase 20 Neighboring gene ncRNA Neighboring gene Protein stum homolog Neighboring gene ncRNA Neighboring gene Homeobox domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Increasing Complexity of the N-Glycome During Caenorhabditis Development. Wilson IBH, et al. Mol Cell Proteomics, 2023 Mar. PMID 36717059, Free PMC Article
  2. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables lysophospholipase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables monoacylglycerol lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables monoacylglycerol lipase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in monoacylglycerol catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylserine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Serine aminopeptidase S33 domain-containing protein
NP_001379898.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    7983879..7985954
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392553.1 → NP_001379898.1  Serine aminopeptidase S33 domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q965S2
    Conserved Domains (1) summary
    pfam12146
    Location:138 → 315
    Hydrolase_4; Serine aminopeptidase, S33
Nucleotide Protein
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