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lmtr-2 Ragulator complex protein LAMTOR2 homolog [ Caenorhabditis elegans ]

Gene ID: 179177, updated on 12-Jun-2024

Summary

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Gene symbol
lmtr-2
Gene description
Ragulator complex protein LAMTOR2 homolog
Locus tag
CELE_Y97E10AR.7
See related
AllianceGenome:WB:WBGene00022402
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to contribute to guanyl-nucleotide exchange factor activity and molecular adaptor activity. Predicted to be involved in several processes, including cellular response to amino acid stimulus; positive regulation of TOR signaling; and regulation of cell growth. Predicted to be part of Ragulator complex. Is expressed in hypodermis and nervous system. Orthologous to human LAMTOR2 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See lmtr-2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
2
Sequence:
Chromosome: V; NC_003283.11 (8010491..8011106, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene SPK domain-containing protein Neighboring gene SPK domain-containing protein Neighboring gene DNA-directed RNA polymerase II subunit rpb-9 Neighboring gene BSD domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  2. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
  3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables molecular adaptor activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to molecular adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cellular response to amino acid stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to amino acid stimulus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of TOR signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of TOR signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein localization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell growth ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of Ragulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Ragulator complex protein LAMTOR2 homolog
NP_505061.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    8010491..8011106 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_072660.8 → NP_505061.1  Ragulator complex protein LAMTOR2 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505061.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9N2U6
    Conserved Domains (1) summary
    pfam03259
    Location:9 → 92
    Robl_LC7; Roadblock/LC7 domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9N2U6.1

Gene LinkOut

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