oma-2 CCCH-type zinc finger protein oma-2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: oma-2
Official Full Name: CCCH-type zinc finger protein oma-2
Primary source: WormBase:WBGene00003865
Locus tag: CELE_ZC513.6
See related: AllianceGenome:WB:WBGene00003865
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables mRNA regulatory element binding translation repressor activity. Involved in several processes, including oocyte development; regulation of cell development; and regulation of protein metabolic process. Located in P granule and centrosome. Is expressed in several structures, including AB; germ line; head muscle; oocyte; and somatic nervous system. Orthologous to human ZFP36L1 (ZFP36 ring finger protein like 1) and ZFP36L2 (ZFP36 ring finger protein like 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See oma-2 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 6

Sequence:: Chromosome: V; NC_003283.11 (8029439..8031214)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

OMA-2 promotes expression of spn-4 and meg-1 during oocyte meiotic maturation and the oocyte-to-embryo transition.
Title: LIN-41 and OMA Ribonucleoprotein Complexes Mediate a Translational Repression-to-Activation Switch Controlling Oocyte Meiotic Maturation and the Oocyte-to-Embryo Transition in Caenorhabditis elegans.
Results suggest that moe-1, -2, and -3 gene products are unique multifunctional proteins in terms of their redundancy and characteristic behaviour during the course of oocyte maturation.
Title: Novel family of CCCH-type zinc-finger proteins, MOE-1, -2 and -3, participates in C. elegans oocyte maturation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F43H9.4 (e-PCR)
- UniSTS:312323

ZC513.6 (e-PCR)
- UniSTS:312478

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA regulatory element binding translation repressor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in establishment of chromosome localization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in meiotic nuclear membrane disassembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of meiotic cell cycle process involved in oocyte maturation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of ovulation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in oocyte maturation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in oocyte morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of MAP kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of embryonic development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of fertilization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of meiotic cell cycle process involved in oocyte maturation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of oocyte development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of oocyte maturation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein localization to chromatin	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in P granule	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: CCCH-type zinc finger protein oma-2

NP_505069.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

8029439..8031214

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_072668.9 → NP_505069.1 CCCH-type zinc finger protein oma-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_505069.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q23359

Conserved Domains (1) summary

cl11592
Location:10 → 172

zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)