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srp-7 Serpin domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 179195, updated on 2-Nov-2024

Summary

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Official Symbol
srp-7
Official Full Name
Serpin domain-containing protein
Primary source
WormBase:WBGene00005648
Locus tag
CELE_F20D6.4
See related
AllianceGenome:WB:WBGene00005648
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable peptidase activity and serine-type endopeptidase inhibitor activity. Involved in IRE1-mediated unfolded protein response. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; Nagashima-type palmoplantar keratosis; autosomal recessive nonsyndromic deafness 91; familial encephalopathy with neuroserpin inclusion bodies; and thrombophilia (multiple). Orthologous to several human genes including SERPINB1 (serpin family B member 1); SERPINB11 (serpin family B member 11); and SERPINB3 (serpin family B member 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See srp-7 in Genome Data Viewer
Location:
chromosome: V
Exon count:
8
Sequence:
Chromosome: V; NC_003283.11 (8179213..8183442)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene GTP-binding protein Rheb Neighboring gene Histone H2A/H2B/H3 domain-containing protein Neighboring gene Serpin domain-containing protein Neighboring gene Methyltransferase FkbM domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Selective conservation of the RSL-encoding, proteinase inhibitory-type, clade L serpins in Caenorhabditis species. Luke CJ, et al. Front Biosci, 2006 Jan 1. PMID 16146754
  2. SRP-2 is a cross-class inhibitor that participates in postembryonic development of the nematode Caenorhabditis elegans: initial characterization of the clade L serpins. Pak SC, et al. J Biol Chem, 2004 Apr 9. PMID 14739286
  3. Molecular phylogeny of the antiangiogenic and neurotrophic serpin, pigment epithelium derived factor in vertebrates. Xu X, et al. BMC Genomics, 2006 Oct 4. PMID 17020603, Free PMC Article
  4. A survival pathway for Caenorhabditis elegans with a blocked unfolded protein response. Urano F, et al. J Cell Biol, 2002 Aug 19. PMID 12186849, Free PMC Article
  5. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. Shen X, et al. PLoS Genet, 2005 Sep. PMID 16184190, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in IRE1-mediated unfolded protein response HEP PubMed 
involved_in endoplasmic reticulum unfolded protein response HEP PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Serpin domain-containing protein
NP_001023823.1
  • Confirmed by transcript evidence
NP_001023824.1
  • Confirmed by transcript evidence
NP_001122924.1
  • Confirmed by transcript evidence
NP_001379840.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    8179213..8183442
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001129452.4 → NP_001122924.1  Serpin domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122924.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A9Z1L1
    Conserved Domains (1) summary
    cd19581
    Location:14 → 372
    serpinL_nematode; serpin family L, serpin family proteins from nematodes

  2. NM_001028652.8 → NP_001023823.1  Serpin domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023823.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6QUQ6
    Conserved Domains (1) summary
    cd19581
    Location:7 → 365
    serpinL_nematode; serpin family L, serpin family proteins from nematodes

  3. NM_001392557.1 → NP_001379840.1  Serpin domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EBT3
    Conserved Domains (1) summary
    cd19581
    Location:7 → 365
    serpinL_nematode; serpin family L, serpin family proteins from nematodes

  4. NM_001028653.5 → NP_001023824.1  Serpin domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023824.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6QUQ5
    Conserved Domains (1) summary
    cd19581
    Location:7 → 363
    serpinL_nematode; serpin family L, serpin family proteins from nematodes
Nucleotide Protein
Heading Accession and Version

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