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tmd-2 Tropomodulin [ Caenorhabditis elegans ]

Gene ID: 179216, updated on 2-Nov-2024

Summary

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Official Symbol
tmd-2
Official Full Name
Tropomodulin
Primary source
WormBase:WBGene00006582
Locus tag
CELE_C08D8.2
See related
AllianceGenome:WB:WBGene00006582
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable tropomyosin binding activity. Predicted to be involved in actin filament organization and myofibril assembly. Located in myofibril. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 2G. Orthologous to human LMOD2 (leiomodin 2) and TMOD4 (tropomodulin 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See tmd-2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
10
Sequence:
Chromosome: V; NC_003283.11 (8334660..8340756)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DUF3951 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Architecture of the cortical actomyosin network driving apical constriction in C. elegans. Zhang P, et al. J Cell Biol, 2023 Sep 4. PMID 37351566, Free PMC Article
  2. Sarcomeric actin organization is synergistically promoted by tropomodulin, ADF/cofilin, AIP1 and profilin in C. elegans. Yamashiro S, et al. J Cell Sci, 2008 Dec 1. PMID 18984629, Free PMC Article
  3. Distinct patterns of gene and protein expression elicited by organophosphorus pesticides in Caenorhabditis elegans. Lewis JA, et al. BMC Genomics, 2009 Apr 29. PMID 19402892, Free PMC Article
  4. Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. Meissner B, et al. PLoS One, 2011. PMID 21611156, Free PMC Article
  5. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. unexpected synergistic functions of tropomodulin with enhancers of actin filament dynamics in Caenorhabditis elegans striated muscle.
    Title: Sarcomeric actin organization is synergistically promoted by tropomodulin, ADF/cofilin, AIP1 and profilin in C. elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables tropomyosin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tropomyosin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in myofibril assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pointed-end actin filament capping IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in myofibril HDA PubMed 
is_active_in myofibril IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Tropomodulin
NP_505151.2
  • Confirmed by transcript evidence
NP_872143.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    8334660..8340756
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_182343.6 → NP_872143.2  Tropomodulin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_872143.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8I7M7

  2. NM_072750.7 → NP_505151.2  Tropomodulin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505151.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KYK4
Nucleotide Protein
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