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vha-18 putative V-type proton ATPase subunit H 1 [ Caenorhabditis elegans ]

Gene ID: 179223, updated on 2-Nov-2024

Summary

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Official Symbol
vha-18
Official Full Name
putative V-type proton ATPase subunit H 1
Primary source
WormBase:WBGene00018698
Locus tag
CELE_F52E1.10
See related
AllianceGenome:WB:WBGene00018698
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in proton transmembrane transport. Predicted to be part of vacuolar proton-transporting V-type ATPase, V1 domain. Orthologous to human ATP6V1H (ATPase H+ transporting V1 subunit H). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See vha-18 in Genome Data Viewer
Location:
chromosome: V
Exon count:
6
Sequence:
Chromosome: V; NC_003283.11 (8411775..8413482, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Phosphatidylinositol-4,5-bisphosphate 4-phosphatase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene C-type lectin domain-containing protein Neighboring gene RNA-binding protein pos-1 Neighboring gene LysM domain-containing protein;Oxidation resistance protein 1 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Variants in ATP6V0A1 cause progressive myoclonus epilepsy and developmental and epileptic encephalopathy. Bott LC, et al. Brain Commun, 2021. PMID 34909687, Free PMC Article
  2. Vacuolar (H+)-ATPases in Caenorhabditis elegans: what can we learn about giant H+ pumps from tiny worms? Lee SK, et al. Biochim Biophys Acta, 2010 Oct. PMID 20637717
  3. An ECM-to-Nucleus Signaling Pathway Activates Lysosomes for C. elegans Larval Development. Miao R, et al. Dev Cell, 2020 Jan 6. PMID 31735670
  4. Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans. Sun Y, et al. Elife, 2020 Jun 2. PMID 32482227, Free PMC Article
  5. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables proton-transporting ATPase activity, rotational mechanism IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of vacuolar proton-transporting V-type ATPase, V1 domain IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative V-type proton ATPase subunit H 1
NP_505171.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    8411775..8413482 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_072770.7 → NP_505171.1  putative V-type proton ATPase subunit H 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505171.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q20666
    Conserved Domains (1) summary
    cd00256
    Location:12 → 445
    VATPase_H; VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q20666.1

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