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lmd-3 LysM domain-containing protein;Oxidation resistance protein 1 [ Caenorhabditis elegans ]

Gene ID: 179225, updated on 2-Nov-2024

Summary

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Official Symbol
lmd-3
Official Full Name
LysM domain-containing protein;Oxidation resistance protein 1
Primary source
WormBase:WBGene00018700
Locus tag
CELE_F52E1.13
See related
AllianceGenome:WB:WBGene00018700
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in determination of adult lifespan; response to heat; and response to oxidative stress. Predicted to be located in mitochondrion. Predicted to be active in nucleus. Is expressed in head; hypodermis; intestine; nervous system; and pharynx. Human ortholog(s) of this gene implicated in cerebellar hyplasia/atrophy, epilepsy, and global developmental delay. Orthologous to several human genes including OXR1 (oxidation resistance 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See lmd-3 in Genome Data Viewer
Location:
chromosome: V
Exon count:
18
Sequence:
Chromosome: V; NC_003283.11 (8415648..8444806, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene C-type lectin domain-containing protein Neighboring gene putative V-type proton ATPase subunit H 1 Neighboring gene RNA-binding protein pos-1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Post-GPI attachment to proteins factor 2 Neighboring gene TransThyretin-Related family domain Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Oxidation resistance 1 is essential for protection against oxidative stress and participates in the regulation of aging in Caenorhabditis elegans. Sanada Y, et al. Free Radic Res, 2014 Aug. PMID 24865925
  2. Base excision repair causes age-dependent accumulation of single-stranded DNA breaks that contribute to Parkinson disease pathology. SenGupta T, et al. Cell Rep, 2021 Sep 7. PMID 34496255, Free PMC Article
  3. Caenorhabditis elegans mutant allele identification by whole-genome sequencing. Sarin S, et al. Nat Methods, 2008 Oct. PMID 18677319, Free PMC Article
  4. The TORC1 phosphoproteome in C. elegans reveals roles in transcription and autophagy. Sewell AK, et al. iScience, 2022 May 20. PMID 35479415, Free PMC Article
  5. A transcriptional cofactor regulatory network for the C. elegans intestine. Horowitz BB, et al. G3 (Bethesda), 2023 Jul 5. PMID 37119809, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
LysM domain-containing protein;Oxidation resistance protein 1
NP_001360511.1
  • Confirmed by transcript evidence
NP_001360537.1
  • Confirmed by transcript evidence
NP_001360538.1
  • Confirmed by transcript evidence
NP_001367831.1
  • Confirmed by transcript evidence
NP_001379939.1
  • Confirmed by transcript evidence
NP_505173.2
  • Confirmed by transcript evidence
NP_505174.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    8415648..8444806 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_072772.4 → NP_505173.2  Oxidation resistance protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505173.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2L003
    Conserved Domains (2) summary
    smart00584
    Location:666 → 838
    TLDc; domain in TBC and LysM domain containing proteins
    pfam01476
    Location:24 → 66
    LysM; LysM domain

  2. NM_001373062.3 → NP_001360511.1  Oxidation resistance protein 1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A486WXA9
    Conserved Domains (2) summary
    smart00584
    Location:658 → 830
    TLDc; domain in TBC and LysM domain containing proteins
    pfam01476
    Location:14 → 56
    LysM; LysM domain

  3. NM_001373063.2 → NP_001360537.1  Oxidation resistance protein 1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A486WTT8
    Conserved Domains (2) summary
    smart00584
    Location:645 → 817
    TLDc; domain in TBC and LysM domain containing proteins
    pfam01476
    Location:3 → 45
    LysM; LysM domain

  4. NM_001373064.1 → NP_001360538.1  Oxidation resistance protein 1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A486WX74
    Conserved Domains (2) summary
    smart00584
    Location:647 → 819
    TLDc; domain in TBC and LysM domain containing proteins
    pfam01476
    Location:3 → 45
    LysM; LysM domain

  5. NM_001392562.1 → NP_001379939.1  Oxidation resistance protein 1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2L004, Q7M3K6
    Conserved Domains (1) summary
    smart00584
    Location:266 → 438
    TLDc; domain in TBC and LysM domain containing proteins

  6. NM_072773.7 → NP_505174.3  Oxidation resistance protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505174.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    G4SHJ1, G4SNG9, Q3Y409
    Conserved Domains (2) summary
    smart00584
    Location:656 → 828
    TLDc; domain in TBC and LysM domain containing proteins
    pfam01476
    Location:14 → 56
    LysM; LysM domain

  7. NM_001380707.1 → NP_001367831.1  LysM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2L005
    Conserved Domains (1) summary
    pfam01476
    Location:24 → 66
    LysM; LysM domain
Nucleotide Protein
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