natc-1 Protein MAK10 homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: natc-1
Official Full Name: Protein MAK10 homolog
Primary source: WormBase:WBGene00020719
Locus tag: CELE_T23B12.4
See related: AllianceGenome:WB:WBGene00020719
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to contribute to peptide alpha-N-acetyltransferase activity. Involved in several processes, including determination of adult lifespan; response to paraquat; and stress response to metal ion. Located in cytoplasm. Orthologous to human NAA35 (N-alpha-acetyltransferase 35, NatC auxiliary subunit). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See natc-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 8

Sequence:: Chromosome: V; NC_003283.11 (8462359..8465569)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A novel biological function for Natc-1 as a modulator of stress resistance and dauer formation and define a functionally significant downstream effector of the insulin/IGF-1 signaling pathway.
Title: The DAF-16 FOXO transcription factor regulates natc-1 to modulate stress resistance in Caenorhabditis elegans, linking insulin/IGF-1 signaling to protein N-terminal acetylation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T23B12.4 (e-PCR)
- UniSTS:312455

T23B12.7 (e-PCR)
- UniSTS:312457

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
contributes_to peptide alpha-N-acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in N-terminal peptidyl-methionine acetylation	IEA Inferred from Electronic Annotation more info
involved_in dauer larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to heat	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to paraquat	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stress response to cadmium ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stress response to copper ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stress response to zinc ion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in stress response to zinc ion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of NatC complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NatC complex	IEA Inferred from Electronic Annotation more info
part_of NatC complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Protein MAK10 homolog

NP_505179.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

8462359..8465569

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_072778.8 → NP_505179.1 Protein MAK10 homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_505179.1

Status: REVIEWED

UniProtKB/TrEMBL

O17003

Conserved Domains (3) summary

pfam04112
Location:28 → 155

Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase

pfam09026
Location:273 → 317

CENP-B_dimeris; Centromere protein B dimerization domain

pfam09184
Location:222 → 306

PPP4R2; PPP4R2