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mod-1 Serotonin-gated chloride channel mod-1 [ Caenorhabditis elegans ]

Gene ID: 179269, updated on 2-Nov-2024

Summary

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Official Symbol
mod-1
Official Full Name
Serotonin-gated chloride channel mod-1
Primary source
WormBase:WBGene00003386
Locus tag
CELE_K06C4.6
See related
AllianceGenome:WB:WBGene00003386
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables serotonin binding activity and serotonin-gated chloride channel activity. Involved in several processes, including behavioral response to starvation; chloride transmembrane transport; and locomotory exploration behavior. Located in neuronal cell body and plasma membrane. Is expressed in body wall musculature and neurons. Used to study cocaine abuse. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mod-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
11
Sequence:
Chromosome: V; NC_003283.11 (8909704..8914040, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Coordinated Behavioral and Physiological Responses to a Social Signal Are Regulated by a Shared Neuronal Circuit. Aprison EZ, et al. Curr Biol, 2019 Dec 2. PMID 31708394, Free PMC Article
  2. MOD-1 is a serotonin-gated chloride channel that modulates locomotory behaviour in C. elegans. Ranganathan R, et al. Nature, 2000 Nov 23. PMID 11100728
  3. Serotonin modulates behavior-related neural activity of RID interneuron in Caenorhabditis elegans. Mori H, et al. PLoS One, 2019. PMID 31800640, Free PMC Article
  4. PharmacoGenetic targeting of a C. elegans essential neuron provides an in vivo screening for novel modulators of nematode ion channel function. Calahorro F, et al. Pestic Biochem Physiol, 2022 Aug. PMID 35973757
  5. The nematode serotonin-gated chloride channel MOD-1: A novel target for anthelmintic therapy. Rodriguez Araujo N, et al. J Biol Chem, 2022 Sep. PMID 35952761, Free PMC Article

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mod-1 is expressed in the neurons and muscles that directly control locomotion.
    Title: Receptors and other signaling proteins required for serotonin control of locomotion in Caenorhabditis elegans.
  2. Mod-1 modulates interneuronal signaling to stimulate reversal and backward locomotion.
    Title: Three distinct amine receptors operating at different levels within the locomotory circuit are each essential for the serotonergic modulation of chemosensation in Caenorhabditis elegans.
  3. the central ring of charge formed by the M2 segments of the 5-hydroxytryptamine-gated chloride channel MOD-1 has a critical role in determining anion/cation permeability
    Title: Chimeric mutations in the M2 segment of the 5-hydroxytryptamine-gated chloride channel MOD-1 define a minimal determinant of anion/cation permeability.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
contributes_to chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables extracellular ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables ligand-gated monoatomic anion channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serotonin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables serotonin receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables serotonin-gated chloride channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in behavioral response to starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chloride transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chloride transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
  
involved_in locomotory exploration behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of fatty acid beta-oxidation by serotonin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of locomotion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of postsynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
  
involved_in sensory perception of chemical stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in serotonin receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in serotonin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transmembrane transporter complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Serotonin-gated chloride channel mod-1
NP_001024034.1
  • Confirmed by transcript evidence
NP_001024035.1
  • Partially confirmed by transcript evidence
NP_741580.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    8909704..8914040 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171495.6 → NP_741580.1  Serotonin-gated chloride channel mod-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741580.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    H2L0B8, Q8MPU3, Q9GQ00, Q9GYH1
    Conserved Domains (3) summary
    TIGR00860
    Location:7 → 479
    LIC; Cation transporter family protein
    pfam02931
    Location:34 → 239
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:247 → 476
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

  2. NM_001028863.5 → NP_001024034.1  Serotonin-gated chloride channel mod-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024034.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MPU3
    Conserved Domains (3) summary
    TIGR00860
    Location:7 → 465
    LIC; Cation transporter family protein
    pfam02931
    Location:34 → 239
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:247 → 462
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

  3. NM_001028864.4 → NP_001024035.1  Serotonin-gated chloride channel mod-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024035.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2L0B8
    Conserved Domains (2) summary
    pfam02931
    Location:34 → 239
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:247 → 327
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9GQ00.1

Gene LinkOut

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