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hsp-16.48 Heat shock protein Hsp-16.48/Hsp-16.49 [ Caenorhabditis elegans ]

Gene ID: 179287, updated on 2-Nov-2024

Summary

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Official Symbol
hsp-16.48
Official Full Name
Heat shock protein Hsp-16.48/Hsp-16.49
Primary source
WormBase:WBGene00002019
Locus tag
CELE_T27E4.3
See related
AllianceGenome:WB:WBGene00002019
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable unfolded protein binding activity. Involved in determination of adult lifespan and response to heat. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including coelomocyte; enteric muscle; intestine; nervous system; and pharynx. Human ortholog(s) of this gene implicated in cataract 9 multiple types. Orthologous to human CRYAA (crystallin alpha A). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hsp-16.48 in Genome Data Viewer
Location:
chromosome: V
Exon count:
2
Sequence:
Chromosome: V; NC_003283.11 (9088131..9088617)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Heat shock protein Hsp-16.1/Hsp-16.11 Neighboring gene Heat shock protein Hsp-16.48/Hsp-16.49 Neighboring gene Heat shock protein Hsp-16.1/Hsp-16.11

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Efficient transcription of a Caenorhabditis elegans heat shock gene pair in mouse fibroblasts is dependent on multiple promoter elements which can function bidirectionally. Kay RJ, et al. Mol Cell Biol, 1986 Sep. PMID 3023964, Free PMC Article
  2. Expression of intron-containing C. elegans heat shock genes in mouse cells demonstrates divergence of 3' splice site recognition sequences between nematodes and vertebrates, and an inhibitory effect of heat shock on the mammalian splicing apparatus. Kay RJ, et al. Nucleic Acids Res, 1987 May 11. PMID 3588308, Free PMC Article
  3. Small Heat Shock Proteins Are Novel Common Determinants of Alcohol and Nicotine Sensitivity in Caenorhabditis elegans. Johnson JR, et al. Genetics, 2016 Mar. PMID 26773049, Free PMC Article
  4. Molecular characterization of a novel, developmentally regulated small embryonic chaperone from Caenorhabditis elegans. Linder B, et al. J Biol Chem, 1996 Nov 22. PMID 8939966
  5. Ethanol Stimulates Locomotion via a G(αs)-Signaling Pathway in IL2 Neurons in Caenorhabditis elegans. Johnson JR, et al. Genetics, 2017 Nov. PMID 28951527, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in IRE1-mediated unfolded protein response HEP PubMed 
involved_in determination of adult lifespan IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to heat IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to heat IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Heat shock protein Hsp-16.48/Hsp-16.49
NP_505355.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    9088131..9088617
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_072954.5 → NP_505355.1  Heat shock protein Hsp-16.48/Hsp-16.49 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505355.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P02513, Q27922
    Conserved Domains (2) summary
    cd06526
    Location:46 → 127
    metazoan_ACD; Alpha-crystallin domain (ACD) of metazoan alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are ...
    COG0071
    Location:46 → 138
    IbpA; Molecular chaperone IbpA, HSP20 family [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P02513.1

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