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ucp-4 UnCoupling Protein (mitochondrial substrate carrier) [ Caenorhabditis elegans ]

Gene ID: 179315, updated on 18-Sep-2024

Summary

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Official Symbol
ucp-4
Official Full Name
UnCoupling Protein (mitochondrial substrate carrier)
Primary source
WormBase:WBGene00006729
Locus tag
CELE_K07B1.3
See related
AllianceGenome:WB:WBGene00006729
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in response to cold. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in body wall musculature; head neurons; hypodermis; and pharynx. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human SLC25A27 (solute carrier family 25 member 27). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ucp-4 in Genome Data Viewer
Location:
chromosome: V
Exon count:
6
Sequence:
Chromosome: V; NC_003283.11 (9334773..9336668)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene NOT2/NOT3/NOT5 C-terminal domain-containing protein Neighboring gene Phospholipid/glycerol acyltransferase domain-containing protein Neighboring gene Acyltransferase Neighboring gene Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial Neighboring gene Target Of Splicing

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Uncoupling Protein, UCP-4 May Be Involved in Neuronal Defects During Aging and Resistance to Pathogens in Caenorhabditis elegans. Cho I, et al. Mol Cells, 2016 Sep. PMID 27646689, Free PMC Article
  2. Caenorhabditis elegans ucp-4 regulates fat metabolism: suppression of ucp-4 expression induced obese phenotype and caused impairment of insulin like pathway. Ji C, et al. Gene, 2012 Jan 10. PMID 22020224
  3. Mitochondrial Uncoupling Attenuates Age-Dependent Neurodegeneration in C. elegans. Cho I, et al. Mol Cells, 2017 Nov 30. PMID 29081084, Free PMC Article
  4. Caenorhabditis elegans UCP4 protein controls complex II-mediated oxidative phosphorylation through succinate transport. Pfeiffer M, et al. J Biol Chem, 2011 Oct 28. PMID 21862587, Free PMC Article
  5. Examination of the requirement for ucp-4, a putative homolog of mammalian uncoupling proteins, for stress tolerance and longevity in C. elegans. Iser WB, et al. Mech Ageing Dev, 2005 Oct. PMID 15893362, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results show that neuronal defects decreased during aging in ucp-4 overexpressing animals and uncouplers-treated ucp-4 mutants. Also, data provide evidence that for a molecular mechanisms underlying the association between mitophagy and age-dependent neurodegeneration.
    Title: Mitochondrial Uncoupling Attenuates Age-Dependent Neurodegeneration in C. elegans.
  2. Our results showed that UCP4 knockdown induced an obese phenotype and impaired the insulin-like pathway, possibly via oxidative stress in C. elegans.
    Title: Caenorhabditis elegans ucp-4 regulates fat metabolism: suppression of ucp-4 expression induced obese phenotype and caused impairment of insulin like pathway.
  3. novel function for ceUCP4 in the regulation of complex II-based metabolism through an unexpected mechanism involving succinate transport.
    Title: Caenorhabditis elegans UCP4 protein controls complex II-mediated oxidative phosphorylation through succinate transport.
  4. ucp-4 is a negative regulator of ATP production in C. elegans, but is not required for normal lifespan.
    Title: Examination of the requirement for ucp-4, a putative homolog of mammalian uncoupling proteins, for stress tolerance and longevity in C. elegans.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in response to cold IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to cold IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
UnCoupling Protein (mitochondrial substrate carrier)
NP_505414.1
  • Product from WormBase gene class ucp;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    9334773..9336668
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073013.8 → NP_505414.1  UnCoupling Protein (mitochondrial substrate carrier) [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505414.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O01883
    Conserved Domains (2) summary
    PTZ00169
    Location:20 → 317
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:115 → 214
    Mito_carr; Mitochondrial carrier protein
Nucleotide Protein
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