wdr-62 Cep57 centrosome microtubule-binding domain-containing protein;Protein kinase domain-containing protein;WD Repeat protein;WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: wdr-62
Official Full Name: Cep57 centrosome microtubule-binding domain-containing protein;Protein kinase domain-containing protein;WD Repeat protein;WD_REPEATS_REGION domain-containing protein
Primary source: WormBase:WBGene00019237
Locus tag: CELE_H24G06.1
See related: AllianceGenome:WB:WBGene00019237
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable kinase activity. Predicted to be involved in centriole replication. Predicted to be active in mitotic spindle. Is expressed in intestine. Human ortholog(s) of this gene implicated in intellectual disability; nephronophthisis 20; polymicrogyria; primary autosomal recessive microcephaly; and primary autosomal recessive microcephaly 2 with or without cortical malformations. Orthologous to several human genes including WDR62 (WD repeat domain 62). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See wdr-62 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 25

Sequence:: Chromosome: V; NC_003283.11 (9444048..9460669)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

H24G06.1 (e-PCR)
- UniSTS:306951

STS5-178 (e-PCR)
- UniSTS:242337

F07D3.1 (e-PCR)
- UniSTS:307432

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in centriole replication	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in mitotic spindle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Cep57 centrosome microtubule-binding domain-containing protein;Protein kinase domain-containing protein;WD Repeat protein;WD_REPEATS_REGION domain-containing protein

NP_001343681.1

Confirmed by transcript evidence

NP_001343682.1

Confirmed by transcript evidence

NP_001343683.1

Confirmed by transcript evidence

NP_001343684.1

Confirmed by transcript evidence

NP_001343852.1

Confirmed by transcript evidence;
Product from WormBase gene class wdr

NP_741593.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

9444048..9460669

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001356730.3 → NP_001343682.1 WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q8WSM1

Conserved Domains (3) summary

COG2319
Location:17 → 257

WD40; WD40 repeat [General function prediction only]

sd00039
Location:496 → 545

7WD40; WD40 repeat [structural motif]

cl25539
Location:355 → 714

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001356729.2 → NP_001343681.1 WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

H2L0C5

Conserved Domains (3) summary

COG2319
Location:17 → 257

WD40; WD40 repeat [General function prediction only]

sd00039
Location:496 → 545

7WD40; WD40 repeat [structural motif]

cl25539
Location:355 → 714

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_171508.4 → NP_741593.2 Cep57 centrosome microtubule-binding domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2C9C3D0
NM_001356731.3 → NP_001343683.1 Protein kinase domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q5TKA5

Conserved Domains (1) summary

pfam11244
Location:17 → 88

Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
NM_001356732.3 → NP_001343684.1 Cep57 centrosome microtubule-binding domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

H2L0C6
NM_001356733.3 → NP_001343852.1 WD Repeat protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2C9C3E2