U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

rgef-1 Ras guanyl-releasing protein 3 [ Caenorhabditis elegans ]

Gene ID: 179344, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
rgef-1
Official Full Name
Ras guanyl-releasing protein 3
Primary source
WormBase:WBGene00009100
Locus tag
CELE_F25B3.3
See related
AllianceGenome:WB:WBGene00009100
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables guanyl-nucleotide exchange factor activity. Involved in chemotaxis and positive regulation of Ras protein signal transduction. Located in cytoplasm and intracellular membrane-bounded organelle. Is expressed in excretory gland cell; nervous system; pharyngeal gland cell; rectal gland cell; and uv1. Human ortholog(s) of this gene implicated in hypertension; immunodeficiency 64; and platelet-type bleeding disorder 18. Orthologous to several human genes including RASGRP1 (RAS guanyl releasing protein 1); RASGRP2 (RAS guanyl releasing protein 2); and RASGRP3 (RAS guanyl releasing protein 3). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See rgef-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
11
Sequence:
Chromosome: V; NC_003283.11 (9556027..9561674, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene EH domain-binding protein 1 Neighboring gene ncRNA Neighboring gene Serine/threonine-protein phosphatase Neighboring gene Uncharacterized protein Neighboring gene CTCK domain-containing protein Neighboring gene RNA polymerase-associated protein RTF1 homolog

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Polyglutamine proteins at the pathogenic threshold display neuron-specific aggregation in a pan-neuronal Caenorhabditis elegans model. Brignull HR, et al. J Neurosci, 2006 Jul 19. PMID 16855087, Free PMC Article
  2. A RasGRP, C. elegans RGEF-1b, couples external stimuli to behavior by activating LET-60 (Ras) in sensory neurons. Chen L, et al. Neuron, 2011 Apr 14. PMID 21482356, Free PMC Article
  3. Somatic expression of unc-54 and vha-6 mRNAs declines but not pan-neuronal rgef-1 and unc-119 expression in aging Caenorhabditis elegans. Adamla F, et al. Sci Rep, 2015 Jun 2. PMID 26031360, Free PMC Article
  4. The recurrent pathogenic Pro890Leu substitution in CLTC causes a generalized defect in synaptic transmission in Caenorhabditis elegans. Pannone L, et al. Front Mol Neurosci, 2023. PMID 37324589, Free PMC Article
  5. Lifespan extension and increased pumping rate accompany pharyngeal muscle-specific expression of nfi-1 in C. elegans. Lazakovitch E, et al. Dev Dyn, 2008 Aug. PMID 18651662

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of Ras protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Ras guanyl-releasing protein 3
NP_001263842.1
  • Partially confirmed by transcript evidence
NP_505469.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    9556027..9561674 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001276913.2 → NP_001263842.1  Ras guanyl-releasing protein 3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001263842.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    K8FDZ6
    Conserved Domains (4) summary
    smart00147
    Location:150 → 388
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00029
    Location:493 → 542
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:423 → 473
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam13499
    Location:427 → 477
    EF-hand_7; EF-hand domain pair

  2. NM_073068.4 → NP_505469.3  Ras guanyl-releasing protein 3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505469.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q19770
    Conserved Domains (4) summary
    smart00147
    Location:150 → 388
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00029
    Location:493 → 542
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:423 → 473
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam13499
    Location:427 → 477
    EF-hand_7; EF-hand domain pair
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous