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tag-120 Transmembrane BAX inhibitor motif-containing protein 4 [ Caenorhabditis elegans ]

Gene ID: 179362, updated on 2-Nov-2024

Summary

Official Symbol
tag-120
Official Full Name
Transmembrane BAX inhibitor motif-containing protein 4
Primary source
WormBase:WBGene00006470
Locus tag
CELE_F40F9.2
See related
AllianceGenome:WB:WBGene00006470
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable calcium channel activity. Predicted to be involved in apoptotic signaling pathway; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; and negative regulation of neuron apoptotic process. Predicted to be active in Golgi apparatus; endoplasmic reticulum; and membrane. Is expressed in excretory system; neurons; and pharyngeal muscle cell. Orthologous to several human genes including GRINA (glutamate ionotropic receptor NMDA type subunit associated protein 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See tag-120 in Genome Data Viewer
Location:
chromosome: V
Exon count:
5
Sequence:
Chromosome: V; NC_003283.11 (9707771..9709814, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene RNA_ligase domain-containing protein Neighboring gene Protein her-1 Neighboring gene Protein lifeguard 1-like Neighboring gene tRNA wybutosine-synthesizing protein 2 homolog Neighboring gene ncRNA Neighboring gene PDZ domain-containing protein

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of neuron apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Transmembrane BAX inhibitor motif-containing protein 4
NP_505501.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    9707771..9709814 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073100.9NP_505501.1  Transmembrane BAX inhibitor motif-containing protein 4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505501.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q20241
    Conserved Domains (1) summary
    cd10428
    Location:21241
    LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis