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aagr-3 Glucosidase II subunit alpha [ Caenorhabditis elegans ]

Gene ID: 179364, updated on 2-Nov-2024

Summary

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Official Symbol
aagr-3
Official Full Name
Glucosidase II subunit alpha
Primary source
WormBase:WBGene00009583
Locus tag
CELE_F40F9.6
See related
AllianceGenome:WB:WBGene00009583
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables alpha-1,4-glucosidase activity. Involved in glycogen catabolic process. Predicted to be located in lysosome. Is expressed in anal depressor muscle; intestine; nervous system; pharynx; and rectal epithelium. Human ortholog(s) of this gene implicated in polycystic kidney disease; polycystic kidney disease 3; and polycystic liver disease. Orthologous to human GANAB (glucosidase II alpha subunit). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See aagr-3 in Genome Data Viewer
Location:
chromosome: V
Exon count:
6
Sequence:
Chromosome: V; NC_003283.11 (9725984..9729512, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Proton-coupled folate transporter Neighboring gene Transcription factor CBF/NF-Y/archaeal histone domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene EF-hand domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Bioinformatic and biochemical studies point to AAGR-1 as the ortholog of human acid alpha-glucosidase in Caenorhabditis elegans. Sikora J, et al. Mol Cell Biochem, 2010 Aug. PMID 20349118
  2. A UPR-independent infection-specific role for a BiP/GRP78 protein in the control of antimicrobial peptide expression in C. elegans epidermis. Couillault C, et al. Virulence, 2012 May 1. PMID 22546897, Free PMC Article
  3. Carbohydrates and glycosylation. Berninsone PM. WormBook, 2006 Dec 18. PMID 18050430, Free PMC Article
  4. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
  5. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables alpha-1,4-glucosidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables alpha-glucosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-glucosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in N-glycan processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycogen catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in lysosome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
Glucosidase II subunit alpha
NP_001263844.1
  • Confirmed by transcript evidence
NP_505507.1
  • Confirmed by transcript evidence
NP_505508.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    9725984..9729512 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073106.2 → NP_505507.1  Glucosidase II subunit alpha [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505507.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q20239
    Conserved Domains (3) summary
    cd06603
    Location:358 → 827
    GH31_GANC_GANAB_alpha; neutral alpha-glucosidase C, neutral alpha-glucosidase AB
    cd14752
    Location:229 → 358
    GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
    pfam17137
    Location:803 → 875
    DUF5110; Domain of unknown function (DUF5110)

  2. NM_073107.8 → NP_505508.1  Glucosidase II subunit alpha [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505508.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U3F8
    Conserved Domains (3) summary
    cd06603
    Location:344 → 813
    GH31_GANC_GANAB_alpha; neutral alpha-glucosidase C, neutral alpha-glucosidase AB
    cd14752
    Location:215 → 344
    GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
    pfam17137
    Location:789 → 861
    DUF5110; Domain of unknown function (DUF5110)

  3. NM_001276915.3 → NP_001263844.1  Glucosidase II subunit alpha [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001263844.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    J7SA48
    Conserved Domains (2) summary
    cd06603
    Location:93 → 562
    GH31_GANC_GANAB_alpha; neutral alpha-glucosidase C, neutral alpha-glucosidase AB
    cd14752
    Location:1 → 93
    GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
Nucleotide Protein
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