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aqp-4 Aquaporin [ Caenorhabditis elegans ]

Gene ID: 179366, updated on 2-Nov-2024

Summary

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Official Symbol
aqp-4
Official Full Name
Aquaporin
Primary source
WormBase:WBGene00000172
Locus tag
CELE_F40F9.9
See related
AllianceGenome:WB:WBGene00000172
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables water channel activity. Involved in water transport. Located in apical plasma membrane. Is expressed in intestine. Orthologous to human AQP8 (aquaporin 8). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See aqp-4 in Genome Data Viewer
Location:
chromosome: V
Exon count:
7
Sequence:
Chromosome: V; NC_003283.11 (9737556..9739740)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Transcription factor CBF/NF-Y/archaeal histone domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene EF-hand domain-containing protein Neighboring gene RING-CH-type domain-containing protein Neighboring gene ncRNA Neighboring gene Signal transducer and activator of transcription b

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Aquaporins-2 and -4 regulate glycogen metabolism and survival during hyposmotic-anoxic stress in Caenorhabditis elegans. LaMacchia JC, et al. Am J Physiol Cell Physiol, 2015 Jul 15. PMID 26017147, Free PMC Article
  2. Functional characterization of a water channel of the nematode Caenorhabditis elegans. Kuwahara M, et al. Biochim Biophys Acta, 2000 Dec 15. PMID 11118622
  3. Isolation of C. elegans deletion mutants following ENU mutagenesis and thermostable restriction enzyme PCR screening. Huang CG, et al. Mol Biotechnol, 2006 Jan. PMID 16382185
  4. Functional analysis of the aquaporin gene family in Caenorhabditis elegans. Huang CG, et al. Am J Physiol Cell Physiol, 2007 May. PMID 17229810
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Aquaporins-2 and -4 regulate glycogen metabolism and survival during hyposmotic-anoxic stress in Caenorhabditis elegans.
    Title: Aquaporins-2 and -4 regulate glycogen metabolism and survival during hyposmotic-anoxic stress in Caenorhabditis elegans.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables channel activity IEA
Inferred from Electronic Annotation
more info
  
enables water channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables water channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in water transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in water transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Aquaporin
NP_505512.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    9737556..9739740
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073111.8 → NP_505512.3  Aquaporin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505512.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EEK0
    Conserved Domains (1) summary
    cd00333
    Location:46 → 264
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
Nucleotide Protein
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