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hrg-3 Heme Responsive Gene [ Caenorhabditis elegans ]

Gene ID: 179369, updated on 2-Nov-2024

Summary

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Official Symbol
hrg-3
Official Full Name
Heme Responsive Gene
Primary source
WormBase:WBGene00010256
Locus tag
CELE_F58E6.7
See related
AllianceGenome:WB:WBGene00010256
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables heme binding activity and heme transmembrane transporter activity. Involved in defense response to Gram-negative bacterium and heme transport. Located in extracellular space. Is expressed in intestinal cell. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hrg-3 in Genome Data Viewer
Location:
chromosome: V
Exon count:
3
Sequence:
Chromosome: V; NC_003283.11 (9756468..9757019)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Major sperm protein Neighboring gene Uncharacterized protein Neighboring gene Transmembrane protein Neighboring gene ncRNA Neighboring gene Homeobox protein unc-42 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Histidine residues are important for preserving the structure and heme binding to the C. elegans HRG-3 heme-trafficking protein. Marciano O, et al. J Biol Inorg Chem, 2015 Dec. PMID 26531103
  2. An intercellular heme-trafficking protein delivers maternal heme to the embryo during development in C. elegans. Chen C, et al. Cell, 2011 May 27. PMID 21620137, Free PMC Article
  3. Heme metabolism and erythropoiesis. Chung J, et al. Curr Opin Hematol, 2012 May. PMID 22406824, Free PMC Article
  4. Heme utilization in the Caenorhabditis elegans hypodermal cells is facilitated by heme-responsive gene-2. Chen C, et al. J Biol Chem, 2012 Mar 16. PMID 22303006, Free PMC Article
  5. HRG-9 homologues regulate haem trafficking from haem-enriched compartments. Sun F, et al. Nature, 2022 Oct. PMID 36261532, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables heme binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables heme transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heme transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Heme Responsive Gene
NP_505518.2
  • Product from WormBase gene class hrg;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    9756468..9757019
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073117.6 → NP_505518.2  Heme Responsive Gene [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505518.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q20983
Nucleotide Protein
Heading Accession and Version

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