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F46B6.5 LisH domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 179373, updated on 2-Nov-2024

Summary

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Official Symbol
F46B6.5
Official Full Name
LisH domain-containing protein
Primary source
WormBase:WBGene00009770
Locus tag
CELE_F46B6.5
See related
AllianceGenome:WB:WBGene00009770
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable GTP binding activity. Predicted to be involved in tRNA methylation and tRNA wobble uridine modification. Predicted to be active in mitochondrion. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See F46B6.5 in Genome Data Viewer
Location:
chromosome: V
Exon count:
9
Sequence:
Chromosome: V; NC_003283.11 (9779611..9783069, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene UPF3 domain-containing protein Neighboring gene Hflx-type G domain-containing protein Neighboring gene Tr-type G domain-containing protein Neighboring gene Zinc finger protein ztf-7

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans. Suen KM, et al. Nat Commun, 2020 Aug 25. PMID 32843637, Free PMC Article
  2. A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. Lenfant N, et al. BMC Genomics, 2010 Nov 26. PMID 21110867, Free PMC Article
  3. SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans. Robert VJ, et al. Development, 2023 Nov 1. PMID 37818613, Free PMC Article
  4. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
  5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA wobble uridine modification IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
LisH domain-containing protein
NP_001023935.1
  • Confirmed by transcript evidence
NP_001256137.1
  • Confirmed by transcript evidence
NP_001256138.1
  • Confirmed by transcript evidence
NP_505524.2
  • Confirmed by transcript evidence
NP_872162.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    9779611..9783069 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_182362.7 → NP_872162.2  LisH domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_872162.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8I4I7
    Conserved Domains (2) summary
    TIGR01622
    Location:433 → 527
    SF-CC1; splicing factor, CC1-like family
    pfam08513
    Location:34 → 58
    LisH

  2. NM_001269209.4 → NP_001256138.1  LisH domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256138.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2L2B2
    Conserved Domains (2) summary
    TIGR01642
    Location:457 → 570
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    pfam08513
    Location:34 → 58
    LisH

  3. NM_073123.5 → NP_505524.2  LisH domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505524.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q20453
    Conserved Domains (2) summary
    TIGR01642
    Location:457 → 570
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    pfam08513
    Location:34 → 58
    LisH

  4. NM_001269208.3 → NP_001256137.1  LisH domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256137.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2L2B3
    Conserved Domains (2) summary
    TIGR01642
    Location:457 → 570
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    pfam08513
    Location:34 → 58
    LisH

  5. NM_001028764.6 → NP_001023935.1  LisH domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023935.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7YTV3
    Conserved Domains (2) summary
    TIGR01642
    Location:457 → 570
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    pfam08513
    Location:34 → 58
    LisH
Nucleotide Protein
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