unc-41 Putative stoned B-like protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: unc-41
Official Full Name: Putative stoned B-like protein
Primary source: WormBase:WBGene00006777
Locus tag: CELE_C27H6.1
See related: AllianceGenome:WB:WBGene00006777
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable clathrin adaptor activity. Involved in positive regulation of locomotion. Located in synapse. Is expressed in nervous system. Orthologous to several human genes including STON2 (stonin 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See unc-41 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 12

Sequence:: Chromosome: V; NC_003283.11 (9966380..9976238, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Involvement of the synaptotagmin/stonin2 system in vesicular transport regulated by semaphorins in Caenorhabditis elegans epidermal cells.
Title: Involvement of the synaptotagmin/stonin2 system in vesicular transport regulated by semaphorins in Caenorhabditis elegans epidermal cells.
UNC-41 acts in the same endocytic pathway as micro2 adaptin.
Title: UNC-41/stonin functions with AP2 to recycle synaptic vesicles in Caenorhabditis elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C27H6.1 (e-PCR)
- UniSTS:309167

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables clathrin adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in clathrin-dependent endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle endocytosis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of AP-2 adaptor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Putative stoned B-like protein

NP_001256157.1

Confirmed by transcript evidence

NP_001256158.1

Partially confirmed by transcript evidence

NP_001256159.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

9966380..9976238 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001269228.3 → NP_001256157.1 Putative stoned B-like protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256157.1

Status: REVIEWED

UniProtKB/Swiss-Prot

E1B6U3, E1B6U4, E1B6U5, P90761

Conserved Domains (2) summary

cl10970
Location:1279 → 1606

AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)

cl17171
Location:1145 → 1193

PH-like; Pleckstrin homology-like domain
NM_001269229.3 → NP_001256158.1 Putative stoned B-like protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256158.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P90761

Conserved Domains (2) summary

cl10970
Location:997 → 1324

AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)

cl17171
Location:863 → 911

PH-like; Pleckstrin homology-like domain
NM_001269230.3 → NP_001256159.1 Putative stoned B-like protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256159.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P90761

Conserved Domains (2) summary

cl10970
Location:906 → 1233

AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)

cl17171
Location:772 → 820

PH-like; Pleckstrin homology-like domain