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trpp-6 Trafficking protein particle complex subunit 6B [ Caenorhabditis elegans ]

Gene ID: 179394, updated on 2-Nov-2024

Summary

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Official Symbol
trpp-6
Official Full Name
Trafficking protein particle complex subunit 6B
Primary source
WormBase:WBGene00010699
Locus tag
CELE_K08H10.9
See related
AllianceGenome:WB:WBGene00010699
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Predicted to be located in Golgi apparatus. Predicted to be part of TRAPP complex. Predicted to be active in cis-Golgi network and trans-Golgi network. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with microcephaly, epilepsy, and brain atrophy. Orthologous to several human genes including TRAPPC6B (trafficking protein particle complex subunit 6B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See trpp-6 in Genome Data Viewer
Location:
chromosome: V
Exon count:
6
Sequence:
Chromosome: V; NC_003283.11 (9991895..9992792)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene MYG1 protein C27H6.8 Neighboring gene Piwi domain-containing protein Neighboring gene pseudo Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The conserved transmembrane protein TMEM-39 coordinates with COPII to promote collagen secretion and regulate ER stress response. Zhang Z, et al. PLoS Genet, 2021 Feb. PMID 33524011, Free PMC Article
  2. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
  3. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
  4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in Golgi vesicle transport IEA
Inferred from Electronic Annotation
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
part_of TRAPP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cis-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Trafficking protein particle complex subunit 6B
NP_505571.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    9991895..9992792
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073170.7 → NP_505571.1  Trafficking protein particle complex subunit 6B [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505571.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XU81
    Conserved Domains (1) summary
    cd14944
    Location:2 → 183
    TRAPPC6A_Trs33; Trs33 subunit of the TRAPP complex
Nucleotide Protein
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