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cul-5 Cullin-5 [ Caenorhabditis elegans ]

Gene ID: 179413, updated on 2-Nov-2024

Summary

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Official Symbol
cul-5
Official Full Name
Cullin-5
Primary source
WormBase:WBGene00000840
Locus tag
CELE_ZK856.1
See related
AllianceGenome:WB:WBGene00000840
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein-macromolecule adaptor activity and ubiquitin protein ligase binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to be part of Cul5-RING ubiquitin ligase complex and SCF ubiquitin ligase complex. Is expressed in several structures, including hypodermis; intestine; nervous system; tail; and vulval muscle. Orthologous to human CUL5 (cullin 5). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cul-5 in Genome Data Viewer
Location:
chromosome: V
Exon count:
15
Sequence:
Chromosome: V; NC_003283.11 (10179535..10183154)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Saposin B-type domain-containing protein Neighboring gene RRM domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. PAR-4 and anillin regulate myosin to coordinate spindle and furrow position during asymmetric division. Pacquelet A, et al. J Cell Biol, 2015 Sep 28. PMID 26416962, Free PMC Article
  2. C. elegans RBX-2-CUL-5- and RBX-1-CUL-2-based complexes are redundant for oogenesis and activation of the MAP kinase MPK-1. Sasagawa Y, et al. FEBS Lett, 2007 Jan 9. PMID 17184777
  3. C. elegans CAND-1 regulates cullin neddylation, cell proliferation and morphogenesis in specific tissues. Bosu DR, et al. Dev Biol, 2010 Oct 1. PMID 20659444, Free PMC Article
  4. The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase. Pintard L, et al. Nature, 2003 Sep 18. PMID 13679921
  5. cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family. Kipreos ET, et al. Cell, 1996 Jun 14. PMID 8681378

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. oocyte maturation from pachytene exit and MPK-1 activation are redundantly controlled by the RBX-2-CUL-5- and RBX-1-CUL-2-based complexes.
    Title: C. elegans RBX-2-CUL-5- and RBX-1-CUL-2-based complexes are redundant for oogenesis and activation of the MAP kinase MPK-1.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein-macromolecule adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Cul5-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Cullin-5
NP_505616.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    10179535..10183154
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073215.8 → NP_505616.2  Cullin-5 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505616.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q23639
    Conserved Domains (2) summary
    smart00884
    Location:692 → 759
    Cullin_Nedd8; Cullin protein neddylation domain
    pfam00888
    Location:7 → 657
    Cullin; Cullin family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q23639.2

Gene LinkOut

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