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ric-4 Synaptosomal-associated protein [ Caenorhabditis elegans ]

Gene ID: 179427, updated on 2-Nov-2024

Summary

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Official Symbol
ric-4
Official Full Name
Synaptosomal-associated protein
Primary source
WormBase:WBGene00004364
Locus tag
CELE_Y22F5A.3
See related
AllianceGenome:WB:WBGene00004364
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable SNAP receptor activity and syntaxin binding activity. Involved in cholinergic synaptic transmission. Located in plasma membrane and synapse. Is expressed in several structures, including excretory gland cell; intestinal cell; nervous system; pharyngeal gland cell; and rectal gland cell. Human ortholog(s) of this gene implicated in Down syndrome and congenital myasthenic syndrome 18. Orthologous to several human genes including SNAP25 (synaptosome associated protein 25). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ric-4 in Genome Data Viewer
Location:
chromosome: V
Exon count:
6
Sequence:
Chromosome: V; NC_003283.11 (10261131..10270314, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Serine/threonine-protein kinase akt-1 Neighboring gene RNA-binding protein RO60 Neighboring gene Nuclear Hormone Receptor family Neighboring gene Serpentine Receptor, class T Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The SNARE complex formed by RIC-4/SEC-22/SYX-2 promotes C. elegans epidermal wound healing. Shao Q, et al. Cell Rep, 2023 Nov 28. PMID 37910502
  2. Neuron cell type-specific SNAP-25 expression driven by multiple regulatory elements in the nematode Caenorhabditis elegans. Hwang SB, et al. J Mol Biol, 2003 Oct 17. PMID 14529613
  3. Interspecies complementation identifies a pathway to assemble SNAREs. Parra-Rivas LA, et al. iScience, 2022 Jul 15. PMID 35754735, Free PMC Article
  4. Presynaptic ryanodine receptors are required for normal quantal size at the Caenorhabditis elegans neuromuscular junction. Liu Q, et al. J Neurosci, 2005 Jul 20. PMID 16033884, Free PMC Article
  5. Tomosyn inhibits synaptic vesicle priming in Caenorhabditis elegans. Gracheva EO, et al. PLoS Biol, 2006 Jul. PMID 16895441, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The plasma membrane-associated SNAREs syntaxin/unc-64 and SNAP-25/ric-4 function in parallel in regulating fat storage in C. elegans and regulate fat storage.
    Title: UNC-64 and RIC-4, the plasma membrane-associated SNAREs syntaxin and SNAP-25, regulate fat storage in nematode Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables syntaxin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic transmission, cholinergic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle fusion to presynaptic active zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic vesicle priming IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in presynapse IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Synaptosomal-associated protein
NP_001123033.1
  • Confirmed by transcript evidence
NP_505641.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    10261131..10270314 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073240.9 → NP_505641.2  Synaptosomal-associated protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505641.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O62414
    Conserved Domains (3) summary
    cd15885
    Location:145 → 203
    SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
    cd15889
    Location:16 → 80
    SNARE_SNAP25N_23N; N-terminal SNARE motif of SNAP25 and SNAP23
    pfam00835
    Location:91 → 143
    SNAP-25; SNAP-25 family

  2. NM_001129561.4 → NP_001123033.1  Synaptosomal-associated protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001123033.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A5PEW5
    Conserved Domains (3) summary
    cd15885
    Location:172 → 230
    SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
    cd15889
    Location:45 → 107
    SNARE_SNAP25N_23N; N-terminal SNARE motif of SNAP25 and SNAP23
    pfam00835
    Location:118 → 170
    SNAP-25; SNAP-25 family
Nucleotide Protein
Heading Accession and Version

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