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cash-1 Striatin N-terminal domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 179445, updated on 2-Nov-2024

Summary

Official Symbol
cash-1
Official Full Name
Striatin N-terminal domain-containing protein
Primary source
WormBase:WBGene00010631
Locus tag
CELE_K07C5.8
See related
AllianceGenome:WB:WBGene00010631
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable calmodulin binding activity. Involved in several processes, including positive regulation of GTPase activity; positive regulation of endocytic recycling; and regulation of Golgi organization. Predicted to be part of FAR/SIN/STRIPAK complex. Is expressed in hypodermis; intestine; nervous system; pharynx; and reproductive system. Orthologous to several human genes including STRN3 (striatin 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See cash-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
9
Sequence:
Chromosome: V; NC_003283.11 (10362261..10365964)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Epoxide hydrolase 2 Neighboring gene putative tubulin polyglutamylase ttll-15 Neighboring gene Serpentine Receptor, class I Neighboring gene UDP-glucuronosyltransferase

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in epithelial tube morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of endocytic recycling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of Golgi organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of FAR/SIN/STRIPAK complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Striatin N-terminal domain-containing protein
NP_001360512.1
  • Confirmed by transcript evidence
NP_505664.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    10362261..10365964
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073263.5NP_505664.2  Striatin N-terminal domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505664.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EE12
    Conserved Domains (3) summary
    cd00200
    Location:354673
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:364411
    7WD40; WD40 repeat [structural motif]
    pfam08232
    Location:25156
    Striatin; Striatin family
  2. NM_001373096.3NP_001360512.1  Striatin N-terminal domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A486WY88
    Conserved Domains (3) summary
    cd00200
    Location:357676
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:367414
    7WD40; WD40 repeat [structural motif]
    pfam08232
    Location:25156
    Striatin; Striatin family