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ppm-1.A Protein phosphatase ppm-1.A [ Caenorhabditis elegans ]

Gene ID: 179469, updated on 2-Nov-2024

Summary

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Official Symbol
ppm-1.A
Official Full Name
Protein phosphatase ppm-1.A
Primary source
WormBase:WBGene00006460
Locus tag
CELE_F25D1.1
See related
AllianceGenome:WB:WBGene00006460
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in negative regulation of ERK1 and ERK2 cascade and negative regulation of stress-activated MAPK cascade. Predicted to be located in synapse. Predicted to be active in cytosol and nucleus. Is expressed in anal depressor muscle; hypodermis; intestine; nervous system; and pharynx. Orthologous to several human genes including PPM1A (protein phosphatase, Mg2+/Mn2+ dependent 1A) and PPM1B (protein phosphatase, Mg2+/Mn2+ dependent 1B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ppm-1.A in Genome Data Viewer
Location:
chromosome: V
Exon count:
7
Sequence:
Chromosome: V; NC_003283.11 (10532890..10536388, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Histone deacetylase domain-containing protein Neighboring gene Interleukin-17 Neighboring gene MFS transporter Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Neuronal development in Caenorhabditis elegans is regulated by inhibition of an MLK MAP kinase pathway. Baker ST, et al. Genetics, 2015 Jan. PMID 25339611, Free PMC Article
  2. PPM-1, a PP2Cα/β phosphatase, regulates axon termination and synapse formation in Caenorhabditis elegans. Tulgren ED, et al. Genetics, 2011 Dec. PMID 21968191, Free PMC Article
  3. Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosis. Asencio C, et al. Cell, 2012 Jul 6. PMID 22770216
  4. Delayed development and lifespan extension as features of metabolic lifestyle alteration in C. elegans under dietary restriction. Szewczyk NJ, et al. J Exp Biol, 2006 Oct. PMID 17023606
  5. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of stress-activated MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Protein phosphatase ppm-1.A
NP_001023842.1
  • Confirmed by transcript evidence
NP_001023843.1
  • Confirmed by transcript evidence
NP_001122929.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    10532890..10536388 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001028671.4 → NP_001023842.1  Protein phosphatase ppm-1.A [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023842.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8WHR6, Q19775, Q7JLJ3
    Conserved Domains (2) summary
    pfam00481
    Location:105 → 374
    PP2C; Protein phosphatase 2C
    cl29762
    Location:375 → 412
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

  2. NM_001028672.8 → NP_001023843.1  Protein phosphatase ppm-1.A [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023843.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q19775
    Conserved Domains (2) summary
    pfam00481
    Location:6 → 273
    PP2C; Protein phosphatase 2C
    cl29762
    Location:274 → 311
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

  3. NM_001129457.4 → NP_001122929.1  Protein phosphatase ppm-1.A [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122929.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q19775
    Conserved Domains (2) summary
    pfam00481
    Location:22 → 291
    PP2C; Protein phosphatase 2C
    cl29762
    Location:292 → 329
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q19775.1

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