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mics-1 Mitochondrial scaffolding protein 1;PDZ domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 179475, updated on 17-Oct-2024

Summary

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Official Symbol
mics-1
Official Full Name
Mitochondrial scaffolding protein 1;PDZ domain-containing protein
Primary source
WormBase:WBGene00011890
Locus tag
CELE_T21C9.1
See related
AllianceGenome:WB:WBGene00011890
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in several processes, including establishment or maintenance of epithelial cell apical/basal polarity; receptor clustering; and receptor localization to synapse. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in basolateral plasma membrane and cell junction. Orthologous to human SYNJ2BP (synaptojanin 2 binding protein). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See mics-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
6
Sequence:
Chromosome: V; NC_003283.11 (10576510..10578326, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Vacuolar protein sorting-associated protein 54 Neighboring gene ncRNA Neighboring gene Amiloride-sensitive sodium channel Neighboring gene Enhancer of rudimentary homolog Neighboring gene LiPid Depleted

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. MICS-1 interacts with mitochondrial ATAD-3 and modulates lifespan in C. elegans. Hoffmann M, et al. Exp Gerontol, 2012 Mar. PMID 22245785
  2. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mitochondrial scaffolding protein 1;PDZ domain-containing protein
NP_001343863.1
  • Partially confirmed by transcript evidence
NP_505712.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    10576510..10578326 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001356737.2 → NP_001343863.1  PDZ domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2C9C3M8
    Conserved Domains (1) summary
    cd00992
    Location:71 → 145
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  2. NM_073311.3 → NP_505712.1  Mitochondrial scaffolding protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505712.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22638
    Conserved Domains (1) summary
    cd00992
    Location:47 → 121
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q22638.2

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