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Naip2 NLR family, apoptosis inhibitory protein 2 [ Mus musculus (house mouse) ]

Gene ID: 17948, updated on 2-Nov-2024

Summary

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Official Symbol
Naip2provided by MGI
Official Full Name
NLR family, apoptosis inhibitory protein 2provided by MGI
Primary source
MGI:MGI:1298226
See related
Ensembl:ENSMUSG00000078945 AllianceGenome:MGI:1298226
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Birc1b; Naip-rs6
Summary
Predicted to enable ATP binding activity; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; and protein serine/threonine kinase binding activity. Involved in defense response to bacterium; detection of bacterium; and pyroptotic inflammatory response. Acts upstream of or within cellular response to estrogen stimulus. Part of IPAF inflammasome complex. Is expressed in several structures, including central nervous system; heart; liver; male reproductive system; and urinary system. Orthologous to human NAIP (NLR family apoptosis inhibitory protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in large intestine adult (RPKM 11.9), colon adult (RPKM 8.3) and 12 other tissues See more
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Genomic context

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See Naip2 in Genome Data Viewer
Location:
13 D1; 13 53.01 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (100280571..100338630, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (100144063..100202122, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3095 Neighboring gene small EDRK-rich factor 1 Neighboring gene survival motor neuron 1 Neighboring gene STARR-seq mESC enhancer starr_35471 Neighboring gene myc induced nuclear antigen pseudogene Neighboring gene NLR family, apoptosis inhibitory protein 1, related sequence 1 Neighboring gene STARR-seq mESC enhancer starr_35472 Neighboring gene STARR-seq mESC enhancer starr_35473 Neighboring gene NLR family, apoptosis inhibitory protein 5 Neighboring gene STARR-seq mESC enhancer starr_35474 Neighboring gene NLR family, apoptosis inhibitory protein 3, pseudogene 1 Neighboring gene NLR family, apoptosis inhibitory protein 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. cDNA cloning and the 5'genomic organization of Naip2, a candidate gene for murine Legionella resistance. Yaraghi Z, et al. Mamm Genome, 1999 Jul. PMID 10384056
  2. NAIP-NLRC4-deficient mice are susceptible to shigellosis. Mitchell PS, et al. Elife, 2020 Oct 19. PMID 33074100, Free PMC Article
  3. Genetic functions of the NAIP family of inflammasome receptors for bacterial ligands in mice. Zhao Y, et al. J Exp Med, 2016 May 2. PMID 27114610, Free PMC Article
  4. Naip5 affects host susceptibility to the intracellular pathogen Legionella pneumophila. Wright EK, et al. Curr Biol, 2003 Jan 8. PMID 12526741
  5. The mouse Naip gene cluster on Chromosome 13 encodes several distinct functional transcripts. Huang S, et al. Mamm Genome, 1999 Oct. PMID 10501978

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Naip1 is uniquely required to detect T3SS needle protein and Naip2 is uniquely required to detect T3SS inner rod protein, but neither Naip1 nor Naip2 is required for detection of flagellin.
    Title: NAIP proteins are required for cytosolic detection of specific bacterial ligands in vivo.
  2. These results provide definitive genetic evidence for the important physiological function of NAIPs in antibacterial defense and inflammatory damage-induced lethality in mice.
    Title: Genetic functions of the NAIP family of inflammasome receptors for bacterial ligands in mice.
  3. activation of caspase-1 by Shigella is triggered by the rod protein MxiI that interacts with Naip2 to induce activation of the Nlrc4 inflammasome independently of the Pkcdelta kinase
    Title: Shigella type III secretion protein MxiI is recognized by Naip2 to induce Nlrc4 inflammasome activation independently of Pkcδ.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC141528

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to estrogen stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to bacterium IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in detection of bacterium IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in detection of bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in pyroptotic inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyroptotic inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_negative_effect regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of IPAF inflammasome complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of IPAF inflammasome complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
baculoviral IAP repeat-containing protein 1b
Names
neuronal apoptosis inhibitory protein, related sequence 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001126182.2 → NP_001119654.1  baculoviral IAP repeat-containing protein 1b

    See identical proteins and their annotated locations for NP_001119654.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AY147001, BY154503, CT030167
    Consensus CDS
    CCDS26726.1
    UniProtKB/Swiss-Prot
    A9C470, O09124, Q9QUK4, Q9R030
    UniProtKB/TrEMBL
    Q540N6, Q8CGT0
    Related
    ENSMUSP00000070827.6, ENSMUST00000067975.12
    Conserved Domains (6) summary
    smart00238
    Location:159 → 229
    BIR; Baculoviral inhibition of apoptosis protein repeat
    smart00382
    Location:507 → 644
    AAA; ATPases associated with a variety of cellular activities
    cd00022
    Location:61 → 129
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd00116
    Location:1106 → 1373
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00034
    Location:1201 → 1226
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam05729
    Location:508 → 662
    NACHT; NACHT domain

  2. NM_010872.3 → NP_035002.2  baculoviral IAP repeat-containing protein 1b

    See identical proteins and their annotated locations for NP_035002.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AY147001, BY154503, CT030167
    Consensus CDS
    CCDS26726.1
    UniProtKB/Swiss-Prot
    A9C470, O09124, Q9QUK4, Q9R030
    UniProtKB/TrEMBL
    Q540N6, Q8CGT0
    Related
    ENSMUSP00000113890.2, ENSMUST00000117913.8
    Conserved Domains (6) summary
    smart00238
    Location:159 → 229
    BIR; Baculoviral inhibition of apoptosis protein repeat
    smart00382
    Location:507 → 644
    AAA; ATPases associated with a variety of cellular activities
    cd00022
    Location:61 → 129
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd00116
    Location:1106 → 1373
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00034
    Location:1201 → 1226
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam05729
    Location:508 → 662
    NACHT; NACHT domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    100280571..100338630 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QUK4.2 GenPept UniProtKB/Swiss-Prot:Q9QUK4

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