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sqv-4 UDP-glucose 6-dehydrogenase [ Caenorhabditis elegans ]

Gene ID: 179484, updated on 2-Nov-2024

Summary

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Official Symbol
sqv-4
Official Full Name
UDP-glucose 6-dehydrogenase
Primary source
WormBase:WBGene00005022
Locus tag
CELE_F29F11.1
See related
AllianceGenome:WB:WBGene00005022
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables UDP-glucose 6-dehydrogenase activity and identical protein binding activity. Involved in several processes, including egg-laying behavior; glycosaminoglycan biosynthetic process; and vulval development. Located in cytoplasm. Is expressed in several structures, including egg-laying apparatus; germ line; hypodermis; oocyte; and spermatheca. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 84. Orthologous to human UGDH (UDP-glucose 6-dehydrogenase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See sqv-4 in Genome Data Viewer
Location:
chromosome: V
Exon count:
4
Sequence:
Chromosome: V; NC_003283.11 (10659635..10661467, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Aquaporin Neighboring gene glucuronosyltransferase Neighboring gene glucuronosyltransferase Neighboring gene Cytoplasmic tRNA 2-thiolation protein 2 Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. sqv mutants of Caenorhabditis elegans are defective in vulval epithelial invagination. Herman T, et al. Proc Natl Acad Sci U S A, 1999 Feb 2. PMID 9927677, Free PMC Article
  2. The Caenorhabditis elegans vulval morphogenesis gene sqv-4 encodes a UDP-glucose dehydrogenase that is temporally and spatially regulated. Hwang HY, et al. Proc Natl Acad Sci U S A, 2002 Oct 29. PMID 12391315, Free PMC Article
  3. Mutations that perturb vulval invagination in C. elegans. Herman T, et al. Cold Spring Harb Symp Quant Biol, 1997. PMID 9598369
  4. Recent advances in the structural biology of chondroitin sulfate and dermatan sulfate. Sugahara K, et al. Curr Opin Struct Biol, 2003 Oct. PMID 14568617
  5. C. elegans pharyngeal morphogenesis requires both de novo synthesis of pyrimidines and synthesis of heparan sulfate proteoglycans. Franks DM, et al. Dev Biol, 2006 Aug 15. PMID 16828468

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables UDP-glucose 6-dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables UDP-glucose 6-dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in UDP-glucuronate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in egg-laying behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glycosaminoglycan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycosaminoglycan biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in morphogenesis of an epithelium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in reproductive process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vulval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
UDP-glucose 6-dehydrogenase
NP_505730.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    10659635..10661467 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073329.11 → NP_505730.1  UDP-glucose 6-dehydrogenase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505730.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q19905
    Conserved Domains (1) summary
    PLN02353
    Location:11 → 471
    PLN02353; probable UDP-glucose 6-dehydrogenase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q19905.1

Gene LinkOut

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