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plrg-1 WD_REPEATS_REGION domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 179500, updated on 2-Nov-2024

Summary

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Official Symbol
plrg-1
Official Full Name
WD_REPEATS_REGION domain-containing protein
Primary source
WormBase:WBGene00006481
Locus tag
CELE_D1054.15
See related
AllianceGenome:WB:WBGene00006481
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of Prp19 complex and catalytic step 2 spliceosome. Is expressed in head; intestine; nervous system; and tail. Orthologous to human PLRG1 (pleiotropic regulator 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See plrg-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
5
Sequence:
Chromosome: V; NC_003283.11 (10806141..10807912, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene O-phosphoseryl-tRNA(Sec) selenium transferase Neighboring gene Pre-mRNA-splicing factor 38 Neighboring gene pseudo Neighboring gene Transposase Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Systematic transcriptome analysis associated with physiological and chronological aging in Caenorhabditis elegans. Ham S, et al. Genome Res, 2022 Nov-Dec. PMID 36351769, Free PMC Article
  2. The Regulatory Landscape of Lineage Differentiation in a Metazoan Embryo. Du Z, et al. Dev Cell, 2015 Sep 14. PMID 26321128, Free PMC Article
  3. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article
  4. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article
  5. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Prp19 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
WD_REPEATS_REGION domain-containing protein
NP_001256259.1
  • Confirmed by transcript evidence
NP_001256260.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    10806141..10807912 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001269330.4 → NP_001256259.1  WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256259.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EEL2
    Conserved Domains (2) summary
    cd00200
    Location:176 → 470
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:189 → 224
    7WD40; WD40 repeat [structural motif]

  2. NM_001269331.3 → NP_001256260.1  WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256260.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5ECP2
    Conserved Domains (2) summary
    cd00200
    Location:120 → 414
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:133 → 168
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein
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