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ctf-4 Minichromosome loss protein Mcl1 middle region domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 179521, updated on 2-Nov-2024

Summary

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Official Symbol
ctf-4
Official Full Name
Minichromosome loss protein Mcl1 middle region domain-containing protein
Primary source
WormBase:WBGene00008921
Locus tag
CELE_F17C11.10
See related
AllianceGenome:WB:WBGene00008921
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable chromatin binding activity. Predicted to be involved in DNA repair; DNA-templated DNA replication; and mitotic cell cycle. Predicted to be part of replication fork protection complex. Predicted to be active in nuclear replication fork. Human ortholog(s) of this gene implicated in cholangiocarcinoma. Orthologous to human WDHD1 (WD repeat and HMG-box DNA binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ctf-4 in Genome Data Viewer
Location:
chromosome: V
Exon count:
8
Sequence:
Chromosome: V; NC_003283.11 (10961834..10965539, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Vacuolar protein-sorting-associated protein 36 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene putative elongation factor 1-gamma Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Synthetic lethal genetic interactions that decrease somatic cell proliferation in Caenorhabditis elegans identify the alternative RFC CTF18 as a candidate cancer drug target. McLellan J, et al. Mol Biol Cell, 2009 Dec. PMID 19846659, Free PMC Article
  2. DNSN-1 recruits GINS for CMG helicase assembly during DNA replication initiation in Caenorhabditis elegans. Xia Y, et al. Science, 2023 Sep 22. PMID 37590372, Free PMC Article
  3. CUL-2(LRR-1) and UBXN-3 drive replisome disassembly during DNA replication termination and mitosis. Sonneville R, et al. Nat Cell Biol, 2017 May. PMID 28368371, Free PMC Article
  4. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article
  5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA-templated DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA-templated DNA replication ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nuclear replication fork IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of replication fork protection complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
Minichromosome loss protein Mcl1 middle region domain-containing protein
NP_505799.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    10961834..10965539 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073398.5 → NP_505799.1  Minichromosome loss protein Mcl1 middle region domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505799.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q19520
    Conserved Domains (3) summary
    sd00039
    Location:154 → 189
    7WD40; WD40 repeat [structural motif]
    pfam12341
    Location:442 → 764
    Mcl1_mid; Minichromosome loss protein, Mcl1, middle region
    cl29593
    Location:112 → 282
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version

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