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isy-1 Protein isy-1 [ Caenorhabditis elegans ]

Gene ID: 179524, updated on 2-Nov-2024

Summary

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Official Symbol
isy-1
Official Full Name
Protein isy-1
Primary source
WormBase:WBGene00009966
Locus tag
CELE_F53B7.3
See related
AllianceGenome:WB:WBGene00009966
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in regulation of primary miRNA processing. Located in nucleus. Is expressed in several structures, including hypodermis and intestine. Orthologous to human ISY1 (ISY1 splicing factor homolog) and ISY1-RAB43 (ISY1-RAB43 readthrough). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See isy-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
4
Sequence:
Chromosome: V; NC_003283.11 (10999663..11000699, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene ncRNA Neighboring gene Activin_recp domain-containing protein Neighboring gene Low-density lipoprotein receptor domain class A Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A genetic program mediates cold-warming response and promotes stress-induced phenoptosis in C. elegans. Jiang W, et al. Elife, 2018 Apr 17. PMID 29664006, Free PMC Article
  2. Mimicking of splicing-related retinitis pigmentosa mutations in C. elegans allow drug screens and identification of disease modifiers. Kukhtar D, et al. Hum Mol Genet, 2020 Mar 27. PMID 31919495
  3. Proteomic analysis reveals CACN-1 is a component of the spliceosome in Caenorhabditis elegans. Doherty MF, et al. G3 (Bethesda), 2014 Jun 19. PMID 24948787, Free PMC Article
  4. LPD-3 as a megaprotein brake for aging and insulin-mTOR signaling in C. elegans. Pandey T, et al. Cell Rep, 2024 Mar 26. PMID 38446666, Free PMC Article
  5. A ZTF-7/RPS-2 complex mediates the cold-warm response in C. elegans. Xu T, et al. PLoS Genet, 2023 Feb. PMID 36763670, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in generation of catalytic spliceosome for second transesterification step IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in generation of catalytic spliceosome for second transesterification step IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA 3'-splice site recognition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of primary miRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Prp19 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of post-mRNA release spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of post-spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Protein isy-1
NP_505803.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    10999663..11000699 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073402.7 → NP_505803.1  Protein isy-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505803.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q20716
    Conserved Domains (1) summary
    pfam06246
    Location:1 → 264
    Isy1; Isy1-like splicing family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q20716.1

Gene LinkOut

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