pptr-2 Serine/threonine protein phosphatase 2A regulatory subunit [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pptr-2
Official Full Name: Serine/threonine protein phosphatase 2A regulatory subunit
Primary source: WormBase:WBGene00007554
Locus tag: CELE_C13G3.3
See related: AllianceGenome:WB:WBGene00007554
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable protein phosphatase activator activity. Involved in P granule assembly. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including anal depressor muscle; intestine; nervous system; reproductive system; and tail. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 35. Orthologous to several human genes including PPP2R5D (protein phosphatase 2 regulatory subunit B'delta). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pptr-2 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 7

Sequence:: Chromosome: V; NC_003283.11 (11027153..11030824, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The PP2A-SUR-6 promotes centriole assembly by protecting ZYG-1 and SAS-5 from degradation.
Title: Protein phosphatase 2A-SUR-6/B55 regulates centriole duplication in C. elegans by controlling the levels of centriole assembly factors.
The PP2A-mediated loading of SAS-6 proteins is critical at the onset of centriole formation.
Title: PP2A phosphatase acts upon SAS-5 to ensure centriole formation in C. elegans embryos.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C13G3.3 (e-PCR)
- UniSTS:307247

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase regulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in P granule assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of protein phosphatase type 2A complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein phosphatase type 2A complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Serine/threonine protein phosphatase 2A regulatory subunit

NP_001122845.1

Confirmed by transcript evidence

NP_001256283.1

Confirmed by transcript evidence

NP_001369938.1

Confirmed by transcript evidence

NP_001369939.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

11027153..11030824 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001383395.2 → NP_001369938.1 Serine/threonine protein phosphatase 2A regulatory subunit [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q17948

Conserved Domains (1) summary

pfam01603
Location:55 → 458

B56; Protein phosphatase 2A regulatory B subunit (B56 family)
NM_001383396.2 → NP_001369939.1 Serine/threonine protein phosphatase 2A regulatory subunit [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q9U3Q1

Conserved Domains (1) summary

pfam01603
Location:59 → 462

B56; Protein phosphatase 2A regulatory B subunit (B56 family)
NM_001129373.4 → NP_001122845.1 Serine/threonine protein phosphatase 2A regulatory subunit [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001122845.1

Status: REVIEWED

UniProtKB/TrEMBL

A9UJN4

Conserved Domains (1) summary

pfam01603
Location:105 → 508

B56; Protein phosphatase 2A regulatory B subunit (B56 family)
NM_001269354.3 → NP_001256283.1 Serine/threonine protein phosphatase 2A regulatory subunit [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256283.1

Status: REVIEWED

UniProtKB/TrEMBL

H9G2X3

Conserved Domains (2) summary

PLN00122
Location:380 → 475

PLN00122; serine/threonine protein phosphatase 2A; Provisional

pfam01603
Location:72 → 475

B56; Protein phosphatase 2A regulatory B subunit (B56 family)