U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

pptr-2 Serine/threonine protein phosphatase 2A regulatory subunit [ Caenorhabditis elegans ]

Gene ID: 179526, updated on 2-Nov-2024

Summary

Official Symbol
pptr-2
Official Full Name
Serine/threonine protein phosphatase 2A regulatory subunit
Primary source
WormBase:WBGene00007554
Locus tag
CELE_C13G3.3
See related
AllianceGenome:WB:WBGene00007554
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein phosphatase activator activity. Involved in P granule assembly. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including anal depressor muscle; intestine; nervous system; reproductive system; and tail. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 35. Orthologous to several human genes including PPP2R5D (protein phosphatase 2 regulatory subunit B'delta). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See pptr-2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
7
Sequence:
Chromosome: V; NC_003283.11 (11027153..11030824, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ELYS Neighboring gene Protein quiver Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein phosphatase regulator activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in P granule assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of protein phosphatase type 2A complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Serine/threonine protein phosphatase 2A regulatory subunit
NP_001122845.1
  • Confirmed by transcript evidence
NP_001256283.1
  • Confirmed by transcript evidence
NP_001369938.1
  • Confirmed by transcript evidence
NP_001369939.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    11027153..11030824 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001383395.2NP_001369938.1  Serine/threonine protein phosphatase 2A regulatory subunit [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q17948
    Conserved Domains (1) summary
    pfam01603
    Location:55458
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
  2. NM_001383396.2NP_001369939.1  Serine/threonine protein phosphatase 2A regulatory subunit [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U3Q1
    Conserved Domains (1) summary
    pfam01603
    Location:59462
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
  3. NM_001129373.4NP_001122845.1  Serine/threonine protein phosphatase 2A regulatory subunit [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122845.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A9UJN4
    Conserved Domains (1) summary
    pfam01603
    Location:105508
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
  4. NM_001269354.3NP_001256283.1  Serine/threonine protein phosphatase 2A regulatory subunit [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256283.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H9G2X3
    Conserved Domains (2) summary
    PLN00122
    Location:380475
    PLN00122; serine/threonine protein phosphatase 2A; Provisional
    pfam01603
    Location:72475
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)